Recent Reviews
All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!
AI-engineered multifunctional nanoplatforms: synergistically bridging precision diagnosis and intelligent therapy in next-generation oncology https://link.springer.com/article/10.1186/s12951-025-03947-1
Antibody-drug conjugates specifically regulate tumor microenvironment: A promising strategy for pancreatic cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S1499387225002243
Benchmarking Protein Nanoparticles for Drug Delivery and Clinical Translation https://onlinelibrary.wiley.com/doi/10.1002/smtd.202501671
Biology and therapeutic potential of extracellular vesicle targeting and uptake https://www.nature.com/articles/s41580-025-00922-4
ECM-responsive nanomedicine to enhance immunotherapy in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S092777652500863X
Machine learning for nanoparticle-based imaging: From rational design to precision diagnosis https://www.sciencedirect.com/science/article/abs/pii/S0001868625003847
Nanomedicine-mediated modulation of tumor metabolism for enhanced immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925012015
Navigating the Endothelial Barrier: A Multiscale Framework for Precision Nanomedicine https://onlinelibrary.wiley.com/doi/10.1002/smll.202511618
The Biology of Endosomal Escape: Strategies for Enhanced Delivery of Therapeutics https://pubs.acs.org/doi/10.1021/acsnano.5c18112
Advances in Stimuli-Responsive Peptide–Polymer Carriers for Mitochondrial Therapeutics https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c01513
AI and organoid platforms for brain-targeted theranostics https://www.thno.org/v16p0876.htm
Clinical translation of nanomedicines for brain diseases: Current challenges and future directions https://www.sciencedirect.com/science/article/abs/pii/S0168365925010405
Drug delivery systems for mitochondrial targeting https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02199e
Emerging nanoparticle-based therapies for pancreatic cancer: Current clinical landscape https://www.sciencedirect.com/science/article/pii/S0169409X25002455
Engineering complexity into protein-based biomaterials for biomedical applications https://www.nature.com/articles/s41578-025-00861-8
Engineering neural recovery: Micro/nano-structured materials for nerve regeneration https://www.sciencedirect.com/science/article/pii/S2590006425011093
Engineering polymeric micelles for targeted drug delivery: “click” chemistry enabled bioconjugation strategies and emerging applications https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb02193f
Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1717062/full
The molecular logic of early metastasis in pancreatic cancer: crosstalk between tumor and microenvironment https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1726581/full
Informing development of brain cancer therapies within “preclinical trials” using ex vivo patient tumors https://www.sciencedirect.com/science/article/pii/S0169409X25002212
Linking nanotechnology and sustainability https://www.nature.com/articles/s41565-025-02105-w
Long-acting lipid-based nanomedicines: rethinking from structure-based rational design to in vivo fate evaluation https://www.sciencedirect.com/science/article/abs/pii/S016836592501079X
Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202416992
Mitochondrial-Based Nanomedicine in Treatment of Liver Cancer https://link.springer.com/article/10.1007/s12033-025-01523-4
Modeling Glioblastoma for Translation: Strengths and Pitfalls of Preclinical Studies https://www.mdpi.com/2079-7737/14/11/1490
Nanomaterial-based therapeutic strategies for spinal cord injury repair: harnessing multifunctionality to overcome pathophysiological challenges https://pubs.rsc.org/en/content/articlelanding/2025/bm/d5bm01238d
Nanomaterials: an overview of current trends and future prospects in neurological disorder treatment https://link.springer.com/article/10.1186/s12967-025-06877-6
Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy https://www.thno.org/v16p1545.htm
Nanomedicines Against Mitochondrial Dysfunction-Induced Metabolic Diseases https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514522
Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy https://link.springer.com/article/10.1007/s12672-025-04088-5
Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma https://www.sciencedirect.com/science/article/pii/S0169409X25002443
Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02259b
Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy https://www.mdpi.com/2072-6694/17/23/3850
Pre-programming the protein corona: From avoidance to endogenous targeting https://www.sciencedirect.com/science/article/abs/pii/S0168365925010612
Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment https://link.springer.com/article/10.1007/s13346-025-02025-1
Recent Advances in Pharmaceutical and Medical Applications in the Area of Selected Porphyrinoids Connected with PLGA or PLGA-Based Modalities https://www.mdpi.com/2073-4360/17/23/3190
Recent advances in potential drug nanocarriers for CNS disorders: a review https://link.springer.com/article/10.1186/s12938-025-01474-6
Reprogramming Immunosuppressive Niches and the Cancer Immunity Cycle in Pancreatic Cancer with Neoantigen mRNA Plus Immune Adjuvant Nanocarrier Strategies https://pubs.acs.org/doi/10.1021/acsnano.5c14753
Targeting MAO offers a novel immunotherapeutic strategy for prostate cancer by modulating the “tumor-stroma-immune” interaction network https://www.sciencedirect.com/science/article/pii/S0304419X25002483
The growing impact of machine learning on drug formulation science https://www.sciencedirect.com/science/article/abs/pii/S0169409X25002467
Tumor microenvironment in glioblastoma: The central role of the hypoxic–necrotic core https://www.sciencedirect.com/science/article/pii/S0304383525007888
Beyond Alzheimer’s disease—translating biomarker insights across CNS diseases https://www.science.org/doi/full/10.1126/scitranslmed.adr2511
Mechanisms of Mitochondrial Transfer Through TNTs: From Organelle Dynamics to Cellular Crosstalk https://www.mdpi.com/1422-0067/26/21/10581
Nanoemulsions as carriers for malignant brain tumors treatment: a scoping review on drugs, natural compounds, and siRNA delivery https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2574249
Advancing glioblastoma therapy with surface-modified nanoparticles https://link.springer.com/article/10.1007/s10072-025-08457-4
Current strategies and novel immunotherapeutic approaches for overcoming immune resistance in glioblastoma https://link.springer.com/article/10.1007/s12672-025-03807-2
Enhanced sonodynamic therapy and theranostic integration for breast cancer treatment: nanomaterial-driven multifunctional platforms https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb01812a
Overcoming standard-of-care resistance in glioblastoma using nanoparticle-based drug delivery targeting the autophagy pathway https://www.sciencedirect.com/science/article/abs/pii/S0006295225005672
PEG alternatives for RNA therapeutics https://www.nature.com/articles/s41563-025-02408-2
Peptide dendrimers: Novel therapeutic opportunities for peptide-based biomaterials in biomedicine https://www.sciencedirect.com/science/article/abs/pii/S0168365925009368
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to-brain delivery approaches for glioblastoma https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578384
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers for combination therapy and advanced targeting https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578376
Targeted immunomodulation for chronic diseases through advanced delivery platforms
https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2580443
The evolution of nanomedicine: The rise of next-generation nanomaterials in cancer nanomedicine https://www.science.org/doi/full/10.1126/sciadv.adx1576
Applying click chemistry principles to the design of tumor-targeted nanosystems https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2567837
Cancer vaccines as enablers of immunotherapy https://www.nature.com/articles/s41590-025-02308-2
Designing around immune memory to counter PEG immunogenicity https://www.nature.com/articles/s41563-025-02383-8
Epithelial-mesenchymal transition https://www.cell.com/cell/fulltext/S0092-8674(25)01025-6
In vitro models of the interplay between glioblastoma and blood–brain barrier for stratifying drug efficacy https://www.sciencedirect.com/science/article/pii/S0169409X25001875
Introduction to nanomedicines for crossing biological barriers https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr90189h
Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00776-2
Microfluidic-based nanocarriers for overcoming biological barriers in therapeutic delivery systems https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02322j
Progress in cancer vaccines enabled by nanotechnology https://www.nature.com/articles/s41565-025-02021-z
Self-driving labs for biotechnology https://www.nature.com/articles/s43588-025-00885-8
The complex and intricate relationship between incremental science, innovation and recognition https://www.sciencedirect.com/science/article/abs/pii/S0169409X25002066
Treating glioblastoma with dextrin-based polymers https://www.tandfonline.com/doi/abs/10.1080/17425247.2025.2570845
Tumor Microenvironment Metabolism-Modulating Nanomedicines for Enhancing Anti-Tumor Immunity https://onlinelibrary.wiley.com/doi/10.1002/smll.202509685
Vascularized Tumor-on-a-Chip Model as a Platform for Studying Tumor-Microenvironment-Drug Interaction https://onlinelibrary.wiley.com/doi/10.1002/mabi.202500240
Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202416085
Effects of nanoparticle physicochemical properties on macrophage polarization https://www.sciencedirect.com/science/article/abs/pii/S0168365925008272
Factors affecting drug delivery system translation: A focus on advanced technologies, biological barriers, and regulatory challenges https://www.sciencedirect.com/science/article/abs/pii/S0168365925007795
High-throughput platforms for machine learning-guided lipid nanoparticle design https://www.nature.com/articles/s41578-025-00831-0
Lymph node targeting nanomedicines for tumor immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0142961225006544
Nanocarrier-mediated drug delivery systems for spinal cord injury treatment https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1660264/full
Nanomaterials research in the age of AI-generated images https://www.nature.com/articles/s41565-025-02025-9
Overcoming the tumor microenvironment in pancreatic cancer via barrier-specific nanoparticle drug delivery https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr01067e
Past, present and future of drug conjugates for cancer therapy https://www.nature.com/articles/s43018-025-01042-w
Peptide-targeted nanoparticles for tumor therapy https://www.sciencedirect.com/science/article/pii/S0168365925008077
Piezodynamic Therapy: Unleashing Mechanical Energy and Featuristic Next Generation Therapeutic Paradigms for Glioblastoma https://pubs.acs.org/doi/10.1021/acsnano.5c11629
Q&A Translational Cancer Nanomedicine https://www.nature.com/articles/s41467-025-63488-x
Recent Advances in Diagnostic Strategies and Nanotechnology-Based Therapies for Ovarian Cancer Treatment https://pubs.acs.org/doi/10.1021/acsabm.5c00777
Smart liposomal systems for brain cancer: Technological innovations in drug delivery https://www.sciencedirect.com/science/article/abs/pii/S0927776525004114
Tailoring Advanced Metal-Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202513609
Temozolomide-Derived Therapeutic Strategies to Overcome Resistance in Glioblastoma https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02019
The coming era of nudge drugs for cancer https://www.sciencedirect.com/science/article/abs/pii/S1535610825003617
The WHO global landscape of cancer clinical trials https://www.nature.com/articles/s41591-025-03926-x
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies https://www.sciencedirect.com/science/article/pii/S0169409X25001826
Tumor Microenvironment-Responsive Nanomedicines for Potentiating Cancer Immunotherapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513567
What Is New in Spinal Cord Injury Management: A Narrative Review on the Emerging Role of Nanotechnology https://www.mdpi.com/2227-9059/13/9/2176
Application of Novel Drug-Delivery Strategies in Neurological Disorders https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202503646
Chemotherapeutic nanoparticles for glioblastoma https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1641752/full
Localized treatment of glioblastoma: a review of clinical strategies and advances in drug delivery systems https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2550239
Multiphysics modelling enhanced by imaging and artificial intelligence for personalised cancer nanomedicine: Foundations for clinical digital twins https://www.sciencedirect.com/science/article/pii/S0168365925007497
Nanomedicine Reimagined: Translational Strategies for Precision Tumor Theranostics https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202510293
Overcoming the blood–brain barrier challenge: nanotechnology-enhanced photodynamic therapy for glioblastoma treatment https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc03192c
Advanced nanotheranostic approaches for targeted glioblastoma treatment: a synergistic fusion of CRISPR-Cas gene editing, AI-driven tumor profiling, and BBB-modulation https://link.springer.com/article/10.1007/s12032-025-02944-6
Advances in paclitaxel nanoformulations: A systematic review of in vivo therapeutic efficacy and safety enhancements https://www.sciencedirect.com/science/article/abs/pii/S0168365925006571
Advancing engineering design strategies for targeted cancer nanomedicine https://www.nature.com/articles/s41568-025-00847-2
Artificial Intelligence-Driven Nanoarchitectonics for Smart Targeted Drug Delivery https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202510239
Bioactive Hydrogels for Spinal Cord Injury Repair: Emphasis on Gelatin and Its Derivatives https://www.mdpi.com/2310-2861/11/7/497