Recently Published Research

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes https://www.nature.com/articles/s41565-024-01785-0

In vitro drug testing using patient-derived ovarian cancer organoids https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-024-01520-2

Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy https://www.nature.com/articles/s41467-024-53010-0

Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00314-3

Designed endocytosis-inducing proteins degrade targets and amplify signals https://www.nature.com/articles/s41586-024-07948-2

Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00314-3

Pluronic F127-Complexed PEGylated Poly(glutamic acid)-Cisplatin Nanomedicine for Enhanced Glioblastoma Therapy https://onlinelibrary.wiley.com/doi/10.1002/marc.202400662

Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy https://www.cell.com/cell/abstract/S0092-8674(24)00904-8

Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery https://www.nature.com/articles/s41563-024-01961-6

Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics https://www.nature.com/articles/s41565-024-01757-4

Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models https://www.sciencedirect.com/science/article/pii/S0168365924005546

Acid-degradable lipid nanoparticles enhance the delivery of mRNA https://www.nature.com/articles/s41565-024-01765-4

Mitigating the Effects of Persistent Antipolymer Immune Reactions in Nanomedicine: Evaluating Materials-Based Approaches Using Molecular Imaging https://pubs.acs.org/doi/abs/10.1021/acsnano.4c07317

Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) https://pubs.acs.org/doi/10.1021/acsmacrolett.4c00400

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity https://www.nature.com/articles/s41587-024-02301-4

Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids https://www.nature.com/articles/s41563-024-01908-x

Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer https://www.nature.com/articles/s41591-024-03075-7

Active control of pharmacokinetics using light-responsive polymer-drug conjugates for boron neutron capture therapy https://www.sciencedirect.com/science/article/pii/S0168365924003493

Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis https://www.science.org/doi/full/10.1126/sciadv.adn6157

Biointerface-Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment https://onlinelibrary.wiley.com/doi/10.1002/adma.202401495

Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing https://www.science.org/doi/full/10.1126/sciadv.adn2332

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S0168365924003559

Fifty years of sciences with Patrick Couvreur https://link.springer.com/article/10.1007/s13346-024-01643-5

Mitochondria-targeted polyprodrug nanoparticles induce mitochondrial stress for immunogenic chemo-photodynamic therapy of ovarian cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365924003560

Sorafenib Encapsulated Poly(ester amide) Nanoparticles for Efficient and Biosafe Prostate Cancer Therapy https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c00345

Synthetic genomic nanomedicine with triple-responsiveness for systemic anti-tumor therapy https://www.sciencedirect.com/science/article/abs/pii/S0021979724012505

Toward an international standardisation roadmap for nanomedicine https://link.springer.com/article/10.1007/s13346-024-01646-2

Particle uptake in cancer cells can predict malignancy and drug resistance using machine learning https://www.science.org/doi/full/10.1126/sciadv.adj4370

Enhanced Tumor Site Accumulation and Therapeutic Efficacy of Extracellular Matrix-Drug Conjugates Targeting Tumor Cells https://onlinelibrary.wiley.com/doi/10.1002/smll.202402040

Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles https://www.science.org/doi/full/10.1126/sciadv.adk9996

A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research https://www.nature.com/articles/s41565-024-01673-7

A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson’s disease–associated glial changes https://www.nature.com/articles/s43587-024-00583-6

Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00145-0

Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys https://www.nature.com/articles/s41467-024-48442-7

Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids https://www.cell.com/cell-stem-cell/abstract/S1934-5909(24)00146-2

Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure https://www.science.org/doi/10.1126/sciadv.adk4492

Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer https://onlinelibrary.wiley.com/doi/10.1002/adhm.202304618

Supramolecular Assembly and Thermogelation Strategies Using Peptide–Polymer Conjugates https://pubs.acs.org/doi/abs/10.1021/acs.biomac.4c00031

hermoresponsive Core-cross-linked Nanoparticles from HA-b-ELP Diblock Copolymers https://pubs.acs.org/doi/abs/10.1021/acs.biomac.4c00137

Thermosensitive polymer prodrug nanoparticles prepared by an all-aqueous nanoprecipitation process and application to combination therapy https://www.sciencedirect.com/science/article/pii/S0168365924002104

Reexamining in vivo fate of paclitaxel-loaded polymeric micelles https://www.sciencedirect.com/science/article/abs/pii/S1748013224001105

Dual-Responsive Nanomedicine Activates Programmed Antitumor Immunity through Targeting Lymphatic System https://pubs.acs.org/doi/10.1021/acsnano.3c11464

A quantitative MRI-based approach to estimate the permeation and retention of nanomedicines in tumors https://www.sciencedirect.com/science/article/pii/S0168365924001718

Advancements in Nanoparticle Characterization https://link.springer.com/protocol/10.1007/978-1-0716-3786-9_1

Amino-Acid-Encoded Bioinspired Supramolecular Self-Assembly of Multimorphological Nanocarriers https://onlinelibrary.wiley.com/doi/10.1002/smll.202311351

Antiangiogenic Therapeutic mRNA Delivery Using Lung-Selective Polymeric Nanomedicine for Lung Cancer Treatment https://pubs.acs.org/doi/10.1021/acsnano.3c13039

Blood–Brain Barrier Penetrating Nanovehicles for Interfering with Mitochondrial Electron Flow in Glioblastoma https://pubs.acs.org/doi/10.1021/acsnano.3c12434

Dendritic Polymer-Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Anti-Tumor Immune Response https://onlinelibrary.wiley.com/doi/10.1002/adma.202401304

Dendronized Polymer-Derived Nanomedicines for Mitochondrial Dynamics Regulation and Immune Modulation https://onlinelibrary.wiley.com/doi/10.1002/adma.202400582

Engineering Mesoscopic 3D Tumor Models with a Self-Organizing Vascularized Matrix https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202303196

Free PEG Suppresses Anaphylaxis to PEGylated Nanomedicine in Swine https://pubs.acs.org/doi/10.1021/acsnano.3c11165

Glycocalyx-Mimicking Nanoparticles with Differential Organ Selectivity for Drug Delivery and Therapy https://onlinelibrary.wiley.com/doi/10.1002/adma.202311283

Nanobody-mediated targeting of zinc phthalocyanine with polymer micelles as nanocarriers https://www.sciencedirect.com/science/article/pii/S0378517324002382

Nanoparticle-Catalyzed Transamination under Tumor Microenvironment Conditions: A Novel Tool to Disrupt the Pool of Amino Acids and GSSG in Cancer Cells https://pubs.acs.org/doi/10.1021/acs.nanolett.3c04947

Multiparametric in vitro and in vivo analysis of the safety profile of self-assembling peptides https://www.nature.com/articles/s41598-024-54051-7

Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity https://onlinelibrary.wiley.com/doi/10.1002/anie.202317817

Personalized Versus Precision Nanomedicine for Treatment of Ovarian Cancer https://onlinelibrary.wiley.com/doi/10.1002/smll.202307462

An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids https://pubs.acs.org/doi/10.1021/acsnano.3c09027

Full-length single-molecule protein fingerprinting https://www.nature.com/articles/s41565-023-01598-7

Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker https://www.sciencedirect.com/science/article/abs/pii/S0168365924000373

Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition https://www.nature.com/articles/s41587-023-02099-7

Biomimetic bright optotheranostics for metastasis monitoring and multimodal image-guided breast cancer therapeutics https://www.sciencedirect.com/science/article/pii/S0168365924000713

Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy https://www.nature.com/articles/s41467-024-44963-3

Differentiating enantiomers by directional rotation of ions in a mass spectrometer https://www.science.org/doi/10.1126/science.adj8342

E-selectin-targeted polymer-doxorubicin conjugate induces regression of established colorectal liver metastases and improves mice survival https://www.sciencedirect.com/science/article/abs/pii/S1748013224000379

Urease-powered nanobots for radionuclide bladder cancer therapy https://www.nature.com/articles/s41565-023-01577-y

Synthesis of Thermo-Responsive Monofunctionalized Diblock Copolymer Worms https://www.mdpi.com/2073-4360/15/23/4590

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective https://www.cell.com/cell/fulltext/S0092-8674(23)01345-4

Simulation of transvascular transport of nanoparticles in tumor microenvironments for drug delivery applications https://www.nature.com/articles/s41598-024-52292-0

Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders https://www.nature.com/articles/s41556-023-01339-x

Single-particle imaging of nanomedicine entering the brain https://www.pnas.org/doi/10.1073/pnas.2309811121

Probing the chemical ‘reactome’ with high-throughput experimentation data https://www.nature.com/articles/s41557-023-01393-w

Site-specific controlled-release nanoparticles for immune reprogramming via dual metabolic inhibition against triple-negative breast cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365923008064

A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells https://www.sciencedirect.com/science/article/pii/S1742706124000023

Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines https://www.sciencedirect.com/science/article/pii/S001430572400017X

Toward the Scalable, Rapid, Reproducible, and Cost-Effective Synthesis of Personalized Nanomedicines at the Point of Care https://pubs.acs.org/doi/10.1021/acs.nanolett.3c04171

Glutamate affects self-assembly, protein corona, and anti-4 T1 tumor effects of melittin/vitamin E-succinic acid-(glutamate)n nanoparticles https://www.sciencedirect.com/science/article/abs/pii/S0168365923007976

Enhanced chemotherapy and anti-metastasis with in situ nanosphere-to-nanofiber transition https://www.sciencedirect.com/science/article/abs/pii/S1748013223003717

Preparation of trastuzumab-DM1 conjugate with a high drug-to-antibody ratio for breast cancer therapy https://www.sciencedirect.com/science/article/abs/pii/S1748013223003833

Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation https://www.sciencedirect.com/science/article/pii/S1549963423000813

A polymeric nanocarrier that eradicates breast cancer stem cells and delivers chemotherapeutic drugs
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-023-00465-9

Chimeric Peptide-Engineered Self-Delivery Nanomedicine for Photodynamic-Triggered Breast Cancer Immunotherapy by Macrophage Polarization https://onlinelibrary.wiley.com/doi/10.1002/smll.202309994

Exploration of a Pretargeted Theranostic Copolymer Employing Inverse Electron-Demand Diels–Alder Conjugation in Ovarian Cancer https://pubs.acs.org/doi/abs/10.1021/acsapm.3c01849

Impact of the physical-chemical properties of poly(lactic acid)–poly(ethylene glycol) polymeric nanoparticles on biodistribution https://www.sciencedirect.com/science/article/abs/pii/S0168365923007605

Microfluidics-Prepared Ultra-small Biomimetic Nanovesicles for Brain Tumor Targeting https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202302302

Poly(lactic-co-glycolic) acid nanoparticles localize in vesicles after diffusing into cells and are retained by intracellular traffic modulators https://www.futuremedicine.com/doi/full/10.2217/nnm-2023-0139

In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells https://www.nature.com/articles/s41596-023-00902-y

A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer https://www.nature.com/articles/s41591-023-02643-7

Optical sequencing of single synthetic polymers https://www.nature.com/articles/s41557-023-01363-2

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance https://pubs.acs.org/doi/10.1021/acsnano.3c05853

DrugGPT: A GPT-based Strategy for Designing Potential Ligands Targeting Specific Proteins https://www.biorxiv.org/content/10.1101/2023.06.29.543848v1.full

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma https://www.science.org/doi/abs/10.1126/scitranslmed.adi1617

A facile, flexible, and multifunctional thermo-chemotherapy system for customized treatment of drug-resistant breast cancer https://www.sciencedirect.com/science/article/pii/S0168365923006600

Differential cellular responses to FDA-approved nanomedicines: an exploration of albumin-based nanocarriers and liposomes in protein corona formation https://pubs.rsc.org/en/content/articlelanding/2023/nr/d3nr04862d

Immunoregulatory liposomes hitchhiking on neutrophils for enhanced carbon ion radiotherapy-assisted immunotherapy of glioblastoma https://www.sciencedirect.com/science/article/abs/pii/S1748013223002864

Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins https://www.nature.com/articles/s41565-023-01514-z

Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma https://link.springer.com/article/10.1007/s13346-023-01456-y

Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice https://pubs.acs.org/doi/10.1021/acsnano.3c04037

Proteomics reveals time-dependent protein corona changes in the intracellular pathway https://www.sciencedirect.com/science/article/pii/S1742706123006104

Mitochondrial-targeted brequinar liposome boosted mitochondrial-related ferroptosis for promoting checkpoint blockade immunotherapy in bladder cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365923006119

Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging https://www.thno.org/v13p4952

Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients https://www.sciencedirect.com/science/article/abs/pii/S0168365923005898

Palbociclib releases the latent differentiation capacity of neuroblastoma cells https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00443-4

Efficacy comparisons of solvent-based paclitaxel, liposomal paclitaxel, nanoparticle albumin-bound paclitaxel, and docetaxel after neoadjuvant systemic treatment in breast cancer https://www.sciencedirect.com/science/article/abs/pii/S1549963423000588

In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity https://www.nature.com/articles/s41563-023-01646-6

Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours https://www.nature.com/articles/s41565-023-01498-w

Conjugation Length-Dependent Raman Scattering Intensity of Conjugated Polymers https://onlinelibrary.wiley.com/doi/10.1002/marc.202300412

An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice https://www.sciencedirect.com/science/article/pii/S0168365923004649

Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365923005321

Spatiotemporally-Programmed Dual-Acid-Sensitive Nanoworms of Albumin-Poly(tertiary amine)-Doxorubicin Conjugates for Enhanced Cancer Chemotherapy https://onlinelibrary.wiley.com/doi/10.1002/adhm.202301890

Nanoparticles that target the mitochondria of tumor cells to restore oxygen supply for photodynamic therapy: Design and preclinical validation against breast cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365923004881

Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202102441

Tuning Polymer Composition Leads to Activity–Stability Tradeoff in Enzyme-Polymer Conjugates https://pubs.acs.org/doi/abs/10.1021/acs.biomac.3c00396

PEG2000-PLA-based nanoscale polymeric micelles reduce paclitaxel-related toxicity in beagle dogs https://www.sciencedirect.com/science/article/abs/pii/S0168365923005515

Dendritic polymer-functionalized nanomedicine potentiates immunotherapy via lethal energy crisis-induced PD-L1 degradation https://www.sciencedirect.com/science/article/abs/pii/S0142961223003022

Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365923005321

Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium vivax https://www.sciencedirect.com/science/article/pii/S0168365923005059

Enhancing chemotherapy for pancreatic cancer through efficient and sustained tumor microenvironment remodeling with a fibroblast-targeted nanosystem https://www.sciencedirect.com/science/article/abs/pii/S0168365923004856

Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination https://www.science.org/doi/abs/10.1126/scitranslmed.abq0603

Stimuli-responsive self-assembled polymer nanoparticles for the oral delivery of antibodies https://www.sciencedirect.com/science/article/abs/pii/S0168365923004686

The exit of nanoparticles from solid tumours https://www.nature.com/articles/s41563-023-01630-0

Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona https://www.nature.com/articles/s41565-023-01455-7

On-chip modeling of physiological and pathological blood-brain barrier microenvironment for studying glial responses to neuroinflammation https://www.sciencedirect.com/science/article/abs/pii/S1748013223001962

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles https://www.nature.com/articles/s41467-023-40453-0

Rational nanoparticle design: Optimization using insights from experiments and mathematical models https://www.sciencedirect.com/science/article/abs/pii/S0168365923004418

Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response https://www.science.org/doi/full/10.1126/sciadv.add9871

Tuning the Cross-Linking Density and Cross-Linker in Core Cross-Linked Polymeric Micelles and Its Effects on the Particle Stability in Human Blood Plasma and Mice https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c00308

Prediction of cancer nanomedicines self-assembled from meta-synergistic drug pairs https://www.sciencedirect.com/science/article/abs/pii/S0168365923004236

Peptide Self-Assembly Controlled Photoligation of Polymers https://pubs.acs.org/doi/abs/10.1021/jacs.3c03961

Overcoming the blood-brain barrier? – prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models https://www.sciencedirect.com/science/article/abs/pii/S0168365923004431

Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route https://www.sciencedirect.com/science/article/abs/pii/S0168365923004005

Identification of the Proteins Determining the Blood Circulation Time of Nanoparticles https://pubs.acs.org/doi/10.1021/acsnano.3c02041

In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy https://onlinelibrary.wiley.com/doi/10.1002/anie.202308413

Long-acting refillable nanofluidic implant confers protection against SHIV infection in nonhuman primates https://www.science.org/doi/10.1126/scitranslmed.adg2887

Nanoparticles Hitchhike on Monocytes for Glioblastoma Treatment after Low-Dose Radiotherapy https://pubs.acs.org/doi/10.1021/acsnano.3c01428

Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers https://pubs.acs.org/doi/10.1021/acsnano.3c01811

μMESH-Enabled Sustained Delivery of Molecular and Nanoformulated Drugs for Glioblastoma Treatment https://pubs.acs.org/doi/10.1021/acsnano.3c01574

Effective nose-to-brain drug delivery using a combination system targeting the olfactory region in monkeys https://www.sciencedirect.com/science/article/pii/S0168365923003759

Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00183-6

Controlled delivery of a neurotransmitter–agonist conjugate for functional recovery after severe spinal cord injury https://www.nature.com/articles/s41565-023-01416-0

Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257

Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy https://www.science.org/doi/full/10.1126/sciadv.adf4098

Transforming Cancer-Associated Fibroblast Barrier into Drug Depots to Boost Chemo-Immunotherapy in “Shooting Fish in a Barrel” Pattern https://pubs.acs.org/doi/10.1021/acsnano.3c02272

Mapping Antibody Domain Exposure on Nanoparticle Surfaces Using DNA-PAINT https://pubs.acs.org/doi/10.1021/acsnano.3c02195

Synthesis, Characterization, and Biological Evaluation of Radiolabeled Glutamine Conjugated Polymeric Nanoparticles: A Simple Approach for Tumor Imaging https://pubs.acs.org/doi/10.1021/acsabm.3c00048

Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone https://www.mdpi.com/1999-4923/15/6/1580

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia https://www.science.org/doi/abs/10.1126/scitranslmed.abm1262

Efficacy and safety of nano-paclitaxel formulation for cancer treatment: evidence from randomized clinical trials https://www.futuremedicine.com/doi/full/10.2217/nnm-2023-0080

Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis https://www.science.org/doi/10.1126/sciadv.adf3887

Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery https://www.nature.com/articles/s41565-023-01381-8

Quality by Design as a Tool in the Optimisation of Nanoparticle Preparation—A Case Study of PLGA Nanoparticles https://www.mdpi.com/1999-4923/15/2/617

Nanoarchitecture-Integrated Hydrogel Systems toward Therapeutic Applications https://pubs.acs.org/doi/10.1021/acsnano.2c12448

Quantifying Intracellular Nanoparticle Distributions with Three-Dimensional Super-Resolution Microscopy https://pubs.acs.org/doi/10.1021/acsnano.2c12808

Can targeted nanoparticles distinguish cancer metastasis from inflammation? https://www.sciencedirect.com/science/article/abs/pii/S0168365923002456

Complex Structures Made Simple – Continuous Flow Production of Core Cross-Linked Polymeric Micelles for Paclitaxel Pro-Drug-Delivery https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202210704

Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00080-6

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00047-8

Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme https://www.nature.com/articles/s41598-023-32257-5

A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200518

Polylactic-co-glycolic acid-based nanoparticles modified with peptides and other linkers cross the blood-brain barrier for targeted drug delivery https://www.futuremedicine.com/doi/10.2217/nnm-2022-0287

Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis https://www.sciencedirect.com/science/article/abs/pii/S1549963423000205

Omics-based approaches for the systematic profiling of mitochondrial biology https://www.sciencedirect.com/science/article/pii/S1097276523001181

Population-based heteropolymer design to mimic protein mixtures https://www.nature.com/articles/s41586-022-05675-0

Sensitive detection of single-nucleotide polymorphisms by conjugated polymers for personalized treatment of hypertension https://www.science.org/doi/abs/10.1126/scitranslmed.abq5753

Vaccine-like nanomedicine for cancer immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365923001256

Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore memory and recognition of Alzheimer’s disease mice https://www.sciencedirect.com/science/article/abs/pii/S1748013223000373

Revealing the In Situ Behavior of Aggregation-Induced Emission Nanoparticles and Their Biometabolic Effects via Mass Spectrometry Imaging https://pubs.acs.org/doi/10.1021/acsnano.2c10058

Targeted poly(L-glutamic acid)-based hybrid peptosomes co-loaded with doxorubicin and USPIONs as a theranostic platform for metastatic breast cancer https://www.sciencedirect.com/science/article/abs/pii/S1549963422001319

Stiff matrix induces exosome secretion to promote tumour growth https://www.nature.com/articles/s41556-023-01092-1

Nanoparticulate Cationic Poly(amino acid)s Block Cancer Metastases by Destructing Neutrophil Extracellular Traps https://pubs.acs.org/doi/10.1021/acsnano.2c11280

Rapid generation of homogenous tumor spheroid microtissues in a scaffold-free platform for high-throughput screening of a novel combination nanomedicine https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282064

Machine-learning-assisted single-vessel analysis of nanoparticle permeability in tumour vasculatures https://www.nature.com/articles/s41565-023-01323-4

Characterization of the structure and control of the blood-nerve barrier identifies avenues for therapeutic delivery https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00002-3

Federated learning for predicting histological response to neoadjuvant chemotherapy in triple-negative breast cancer https://www.nature.com/articles/s41591-022-02155-w

Combination of hyaluronic acid conjugates with immunogenic cell death inducer and CpG for glioblastoma local chemo-immunotherapy elicits an immune response and induces long-term survival https://www.sciencedirect.com/science/article/abs/pii/S0142961223000145

Endosomal sorting results in a selective separation of the protein corona from nanoparticles https://www.nature.com/articles/s41467-023-35902-9

Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00490-6

Nanocracker capable of simultaneously reversing both P-glycoprotein and tumor microenvironment https://www.sciencedirect.com/science/article/abs/pii/S0168365922008756

Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells https://www.sciencedirect.com/science/article/pii/S2452199X23000051

Immune Exosomes Loading Self-Assembled Nanomicelles Traverse the Blood–Brain Barrier for Chemo-immunotherapy against Glioblastoma https://pubs.acs.org/doi/10.1021/acsnano.2c10219

A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma https://link.springer.com/article/10.1007/s13346-022-01268-6

Micro and nanotechnologies: The little formulations that could https://aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10421

HPMA copolymer-collagen hybridizing peptide conjugates targeted to breast tumor extracellular matrix https://www.sciencedirect.com/science/article/abs/pii/S0168365922006873

Delineating the tumour microenvironment response to a lipid nanoparticle formulation https://www.sciencedirect.com/science/article/abs/pii/S0168365922008355

Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies https://pubs.acs.org/doi/10.1021/acsnano.2c03990

Extracellular matrix degrading enzyme with stroma-targeting peptides enhance the penetration of liposomes into tumors https://www.sciencedirect.com/science/article/abs/pii/S0168365922007489

Microfluidic preparation and optimization of sorafenib-loaded poly(ethylene glycol-block-caprolactone) nanoparticles for cancer therapy applications https://www.sciencedirect.com/science/article/pii/S0021979722020987

Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung https://www.nature.com/articles/s41563-022-01404-0

Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy https://www.nature.com/articles/s41565-022-01266-2

Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of postsurgical cancer recurrence and metastasis https://www.science.org/doi/full/10.1126/sciadv.add3599

Glioblastoma immuno-endothelial multicellular microtissue as a 3D in vitro evaluation tool of anti-cancer nano-therapeutics https://www.sciencedirect.com/science/article/pii/S0168365922007684

Tumor microenvironment-modulated multiple nanotherapeutic system for potent cancer immunotherapy and metastasis inhibition https://www.sciencedirect.com/science/article/abs/pii/S1748013222003309

Engineering nanoparticle communication in living systems by stigmergy: An application to enhance antitumor therapy in triple-negative breast cancer https://www.sciencedirect.com/science/article/abs/pii/S1748013222003206

Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis https://pubs.acs.org/doi/10.1021/acsnano.2c07843

Covalent Conjugate of Ser-Pro-Cys Tripeptide with PEGylated Comb-Like Polymer as Novel Killer of Human Tumor Cells https://pubs.acs.org/doi/full/10.1021/acsomega.2c03611

Engineered Ultrasmall Nanoparticle Drug-Immune Conjugates with “Hit and Run” Tumor Delivery to Eradicate Gastric Cancer https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202200209

Redox-Triggered Nanomedicine via Lymphatic Delivery: Inhibition of Melanoma Growth by Ferroptosis Enhancement and a Pt(IV)-Prodrug Chemoimmunotherapy Approach https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202200179

Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis https://pubs.acs.org/doi/abs/10.1021/acsnano.2c07843