Recent Reviews

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

Applications of engineered peptide nanomaterials in enhanced cancer imaging https://www.tandfonline.com/doi/full/10.1080/17435889.2026.2623935

Artificial intelligence-powered nanomedicine https://pubs.rsc.org/en/content/articlelanding/2026/cs/d5cs01406a

Biofluid biomarkers in Alzheimer’s disease and other neurodegenerative dementias https://www.nature.com/articles/s41586-025-10018-w

Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00456-4

Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to-brain delivery approaches for glioblastoma https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578384

Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers for combination therapy and advanced targeting https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578376

Traceless linkers used for reversible protein–polymer conjugations https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc05801e

Regulatory framework for polymer-based nanotherapeutics in clinical translation https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1735885/full

Artificial intelligence and machine learning guided optimization in drug delivery https://www.sciencedirect.com/science/article/pii/S0169409X26000153

Bioconvergence of sound-guided and supramolecular assembly strategies to create peptide-protein composite hydrogels with predictable shape-to-function features https://www.sciencedirect.com/science/article/pii/S2590006425012153

Circular RNA-Mediated Tumor Immune Escape: Mechanistic Architecture and Nanomedicine-Enabled Therapeutic Reprogramming https://www.sciencedirect.com/science/article/abs/pii/S1040842826000466

Conductive hydrogel combined with electrical stimulation remodels the microenvironment for nerve regeneration to promote spinal cord injury repair https://link.springer.com/article/10.1186/s12951-025-03969-9

Hallmarks of cancer—Then and now, and beyond https://www.cell.com/cell/fulltext/S0092-8674(25)01498-9

Long-acting nanomedicine for brain diseases https://www.sciencedirect.com/science/article/abs/pii/S0168365926000660

Synergies between data science methods and innovative drug delivery technologies https://www.sciencedirect.com/science/article/abs/pii/S0169409X26000177

The RNA delivery dilemma—lipid versus polymer nanoparticle platforms https://link.springer.com/article/10.1007/s13346-026-02044-6

Tumor microenvironment in glioblastoma: The central role of the hypoxic–necrotic core https://www.sciencedirect.com/science/article/pii/S0304383525007888

Bioconjugates for improved delivery of oligonucleotide therapeutics to the central nervous system https://www.sciencedirect.com/science/article/abs/pii/S0169409X26000128

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity https://www.nature.com/articles/s43018-025-01097-9

Nanoparticle-driven therapeutic vaccines: recent advances and future challenges https://link.springer.com/article/10.1007/s44374-025-00008-3

Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics https://www.sciencedirect.com/science/article/abs/pii/S0169409X2600013X

Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma https://www.sciencedirect.com/science/article/pii/S0169409X25002443

Targeted immunotherapies and nanomedicines for ovarian cancer: the way forward https://www.nature.com/articles/s41698-025-01204-0

Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities https://www.mdpi.com/2072-6694/18/1/151

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202519213

AI-engineered multifunctional nanoplatforms: synergistically bridging precision diagnosis and intelligent therapy in next-generation oncology https://link.springer.com/article/10.1186/s12951-025-03947-1

Antibody-drug conjugates specifically regulate tumor microenvironment: A promising strategy for pancreatic cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S1499387225002243

Benchmarking Protein Nanoparticles for Drug Delivery and Clinical Translation https://onlinelibrary.wiley.com/doi/10.1002/smtd.202501671

Biology and therapeutic potential of extracellular vesicle targeting and uptake https://www.nature.com/articles/s41580-025-00922-4

ECM-responsive nanomedicine to enhance immunotherapy in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S092777652500863X

Machine learning for nanoparticle-based imaging: From rational design to precision diagnosis https://www.sciencedirect.com/science/article/abs/pii/S0001868625003847

Nanomedicine-mediated modulation of tumor metabolism for enhanced immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925012015

Navigating the Endothelial Barrier: A Multiscale Framework for Precision Nanomedicine https://onlinelibrary.wiley.com/doi/10.1002/smll.202511618

The Biology of Endosomal Escape: Strategies for Enhanced Delivery of Therapeutics https://pubs.acs.org/doi/10.1021/acsnano.5c18112

Advances in Stimuli-Responsive Peptide–Polymer Carriers for Mitochondrial Therapeutics https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c01513

AI and organoid platforms for brain-targeted theranostics https://www.thno.org/v16p0876.htm

Clinical translation of nanomedicines for brain diseases: Current challenges and future directions https://www.sciencedirect.com/science/article/abs/pii/S0168365925010405

Drug delivery systems for mitochondrial targeting https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02199e

Emerging nanoparticle-based therapies for pancreatic cancer: Current clinical landscape https://www.sciencedirect.com/science/article/pii/S0169409X25002455

Engineering complexity into protein-based biomaterials for biomedical applications https://www.nature.com/articles/s41578-025-00861-8

Engineering neural recovery: Micro/nano-structured materials for nerve regeneration https://www.sciencedirect.com/science/article/pii/S2590006425011093

Engineering polymeric micelles for targeted drug delivery: “click” chemistry enabled bioconjugation strategies and emerging applications https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb02193f

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1717062/full

The molecular logic of early metastasis in pancreatic cancer: crosstalk between tumor and microenvironment https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1726581/full

Informing development of brain cancer therapies within “preclinical trials” using ex vivo patient tumors https://www.sciencedirect.com/science/article/pii/S0169409X25002212

Linking nanotechnology and sustainability https://www.nature.com/articles/s41565-025-02105-w

Long-acting lipid-based nanomedicines: rethinking from structure-based rational design to in vivo fate evaluation https://www.sciencedirect.com/science/article/abs/pii/S016836592501079X

Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202416992

Mitochondrial-Based Nanomedicine in Treatment of Liver Cancer https://link.springer.com/article/10.1007/s12033-025-01523-4

Modeling Glioblastoma for Translation: Strengths and Pitfalls of Preclinical Studies https://www.mdpi.com/2079-7737/14/11/1490

Nanomaterial-based therapeutic strategies for spinal cord injury repair: harnessing multifunctionality to overcome pathophysiological challenges https://pubs.rsc.org/en/content/articlelanding/2025/bm/d5bm01238d

Nanomaterials: an overview of current trends and future prospects in neurological disorder treatment https://link.springer.com/article/10.1186/s12967-025-06877-6

Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy https://www.thno.org/v16p1545.htm

Nanomedicines Against Mitochondrial Dysfunction-Induced Metabolic Diseases https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514522

Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy https://link.springer.com/article/10.1007/s12672-025-04088-5

Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma https://www.sciencedirect.com/science/article/pii/S0169409X25002443

Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02259b

Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy https://www.mdpi.com/2072-6694/17/23/3850

Pre-programming the protein corona: From avoidance to endogenous targeting https://www.sciencedirect.com/science/article/abs/pii/S0168365925010612

Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment https://link.springer.com/article/10.1007/s13346-025-02025-1

Recent Advances in Pharmaceutical and Medical Applications in the Area of Selected Porphyrinoids Connected with PLGA or PLGA-Based Modalities https://www.mdpi.com/2073-4360/17/23/3190

Recent advances in potential drug nanocarriers for CNS disorders: a review https://link.springer.com/article/10.1186/s12938-025-01474-6

Reprogramming Immunosuppressive Niches and the Cancer Immunity Cycle in Pancreatic Cancer with Neoantigen mRNA Plus Immune Adjuvant Nanocarrier Strategies https://pubs.acs.org/doi/10.1021/acsnano.5c14753

Targeting MAO offers a novel immunotherapeutic strategy for prostate cancer by modulating the “tumor-stroma-immune” interaction network https://www.sciencedirect.com/science/article/pii/S0304419X25002483

The growing impact of machine learning on drug formulation science https://www.sciencedirect.com/science/article/abs/pii/S0169409X25002467

Tumor microenvironment in glioblastoma: The central role of the hypoxic–necrotic core https://www.sciencedirect.com/science/article/pii/S0304383525007888

Beyond Alzheimer’s disease—translating biomarker insights across CNS diseases https://www.science.org/doi/full/10.1126/scitranslmed.adr2511

Mechanisms of Mitochondrial Transfer Through TNTs: From Organelle Dynamics to Cellular Crosstalk https://www.mdpi.com/1422-0067/26/21/10581

Nanoemulsions as carriers for malignant brain tumors treatment: a scoping review on drugs, natural compounds, and siRNA delivery https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2574249

Advancing glioblastoma therapy with surface-modified nanoparticles https://link.springer.com/article/10.1007/s10072-025-08457-4

Current strategies and novel immunotherapeutic approaches for overcoming immune resistance in glioblastoma https://link.springer.com/article/10.1007/s12672-025-03807-2

Enhanced sonodynamic therapy and theranostic integration for breast cancer treatment: nanomaterial-driven multifunctional platforms https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb01812a

Overcoming standard-of-care resistance in glioblastoma using nanoparticle-based drug delivery targeting the autophagy pathway https://www.sciencedirect.com/science/article/abs/pii/S0006295225005672

PEG alternatives for RNA therapeutics https://www.nature.com/articles/s41563-025-02408-2

Peptide dendrimers: Novel therapeutic opportunities for peptide-based biomaterials in biomedicine https://www.sciencedirect.com/science/article/abs/pii/S0168365925009368

Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers for combination therapy and advanced targeting https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578376

Targeted immunomodulation for chronic diseases through advanced delivery platforms

https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2580443

The evolution of nanomedicine: The rise of next-generation nanomaterials in cancer nanomedicine https://www.science.org/doi/full/10.1126/sciadv.adx1576

Applying click chemistry principles to the design of tumor-targeted nanosystems https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2567837

Cancer vaccines as enablers of immunotherapy https://www.nature.com/articles/s41590-025-02308-2

Designing around immune memory to counter PEG immunogenicity https://www.nature.com/articles/s41563-025-02383-8

Epithelial-mesenchymal transition https://www.cell.com/cell/fulltext/S0092-8674(25)01025-6

In vitro models of the interplay between glioblastoma and blood–brain barrier for stratifying drug efficacy https://www.sciencedirect.com/science/article/pii/S0169409X25001875

Introduction to nanomedicines for crossing biological barriers https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr90189h

Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00776-2

Microfluidic-based nanocarriers for overcoming biological barriers in therapeutic delivery systems https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02322j

Progress in cancer vaccines enabled by nanotechnology https://www.nature.com/articles/s41565-025-02021-z

Self-driving labs for biotechnology https://www.nature.com/articles/s43588-025-00885-8

The complex and intricate relationship between incremental science, innovation and recognition https://www.sciencedirect.com/science/article/abs/pii/S0169409X25002066

Treating glioblastoma with dextrin-based polymers https://www.tandfonline.com/doi/abs/10.1080/17425247.2025.2570845

Tumor Microenvironment Metabolism-Modulating Nanomedicines for Enhancing Anti-Tumor Immunity https://onlinelibrary.wiley.com/doi/10.1002/smll.202509685

Vascularized Tumor-on-a-Chip Model as a Platform for Studying Tumor-Microenvironment-Drug Interaction https://onlinelibrary.wiley.com/doi/10.1002/mabi.202500240

Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202416085

Effects of nanoparticle physicochemical properties on macrophage polarization https://www.sciencedirect.com/science/article/abs/pii/S0168365925008272

Factors affecting drug delivery system translation: A focus on advanced technologies, biological barriers, and regulatory challenges https://www.sciencedirect.com/science/article/abs/pii/S0168365925007795

High-throughput platforms for machine learning-guided lipid nanoparticle design https://www.nature.com/articles/s41578-025-00831-0

Lymph node targeting nanomedicines for tumor immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0142961225006544

Nanocarrier-mediated drug delivery systems for spinal cord injury treatment https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1660264/full