Recent Reviews

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

From cold to hot: A ‘Prime, Activate, Sustain’ framework for precision remodeling of the tumor microenvironment in prostate cancer https://www.sciencedirect.com/science/article/abs/pii/S1040842826001708

The importance of particle shape in drug delivery https://www.nature.com/articles/s44222-026-00429-3

Bioactive Poly(amino acid) Nanomaterials Potentiate Cancer Immunotherapy https://pubs.acs.org/doi/10.1021/acs.biomac.5c02318

Biomolecular profiling for noninvasive health monitoring https://www.nature.com/articles/s41587-026-03050-2

Clinical development of cancer vaccines https://www.nature.com/articles/s41591-026-04241-9

Enzyme-responsive targeted nanomedicines: a novel strategy for cancer therapy https://pubs.rsc.org/en/content/articlelanding/2026/tb/d6tb00076b

Nanoengineering of Porphyrin-Based Biomaterials for Innovative Cancer Therapy https://onlinelibrary.wiley.com/doi/10.1002/tcr.202500306

Nanomaterials regulate cellular functions and influence cell fate through mitophagy https://www.sciencedirect.com/science/article/abs/pii/S016836592600218X

Nanomedicine-Mediated Immunotherapy for Cancer Treatment https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c02061

Advances in non-invasive delivery strategies for anti-cancer therapy https://www.sciencedirect.com/science/article/abs/pii/S0168365926001756

From conventional screening to self-driving discovery: Organ-on-Chip platforms as engines for AI-guided nanomedicine https://www.sciencedirect.com/science/article/pii/S0169409X26000694

Nanodrug delivery systems in tumor immunotherapy: From immune activation to tumor reprogramming https://www.sciencedirect.com/science/article/abs/pii/S0169409X26000724

The multiverse of zebrafish within the nanoworld https://www.sciencedirect.com/science/article/pii/S0168365926001604

Antibody-nanoparticle conjugates for precision targeting of immunosuppressive tumor microenvironment https://www.sciencedirect.com/science/article/abs/pii/S104084282600106X

Bioactive Poly(amino acid) Nanomaterials Potentiate Cancer Immunotherapy https://pubs.acs.org/doi/10.1021/acs.biomac.5c02318

Mapping the molecular landscape of glioblastoma: Pathogenesis, therapeutic targets and bioactive interventions https://www.sciencedirect.com/science/article/abs/pii/S1040842826000934

Matrix-integrated microfluidic tumor models for evaluating drug delivery systems and pre-clinical testing https://www.sciencedirect.com/science/article/pii/S0169409X26000700

Smart alginate-based biomaterials for neurodegenerative disease therapy: Innovations in delivery, regeneration, and clinical translation https://www.sciencedirect.com/science/article/abs/pii/S0141813026006148

Stimuli-Responsive Supramolecular Biomaterials for Cancer Theranostics https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202515860

Applications of engineered peptide nanomaterials in enhanced cancer imaging https://www.tandfonline.com/doi/full/10.1080/17435889.2026.2623935

Artificial intelligence-powered nanomedicine https://pubs.rsc.org/en/content/articlelanding/2026/cs/d5cs01406a

Biofluid biomarkers in Alzheimer’s disease and other neurodegenerative dementias https://www.nature.com/articles/s41586-025-10018-w

Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00456-4

Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to-brain delivery approaches for glioblastoma https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578384

Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers for combination therapy and advanced targeting https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578376

Traceless linkers used for reversible protein–polymer conjugations https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc05801e

Regulatory framework for polymer-based nanotherapeutics in clinical translation https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1735885/full

Artificial intelligence and machine learning guided optimization in drug delivery https://www.sciencedirect.com/science/article/pii/S0169409X26000153

Bioconvergence of sound-guided and supramolecular assembly strategies to create peptide-protein composite hydrogels with predictable shape-to-function features https://www.sciencedirect.com/science/article/pii/S2590006425012153

Circular RNA-Mediated Tumor Immune Escape: Mechanistic Architecture and Nanomedicine-Enabled Therapeutic Reprogramming https://www.sciencedirect.com/science/article/abs/pii/S1040842826000466

Conductive hydrogel combined with electrical stimulation remodels the microenvironment for nerve regeneration to promote spinal cord injury repair https://link.springer.com/article/10.1186/s12951-025-03969-9

Hallmarks of cancer—Then and now, and beyond https://www.cell.com/cell/fulltext/S0092-8674(25)01498-9

Long-acting nanomedicine for brain diseases https://www.sciencedirect.com/science/article/abs/pii/S0168365926000660

Synergies between data science methods and innovative drug delivery technologies https://www.sciencedirect.com/science/article/abs/pii/S0169409X26000177

The RNA delivery dilemma—lipid versus polymer nanoparticle platforms https://link.springer.com/article/10.1007/s13346-026-02044-6

Tumor microenvironment in glioblastoma: The central role of the hypoxic–necrotic core https://www.sciencedirect.com/science/article/pii/S0304383525007888

Bioconjugates for improved delivery of oligonucleotide therapeutics to the central nervous system https://www.sciencedirect.com/science/article/abs/pii/S0169409X26000128

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity https://www.nature.com/articles/s43018-025-01097-9

Nanoparticle-driven therapeutic vaccines: recent advances and future challenges https://link.springer.com/article/10.1007/s44374-025-00008-3

Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics https://www.sciencedirect.com/science/article/abs/pii/S0169409X2600013X

Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma https://www.sciencedirect.com/science/article/pii/S0169409X25002443

Targeted immunotherapies and nanomedicines for ovarian cancer: the way forward https://www.nature.com/articles/s41698-025-01204-0

Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities https://www.mdpi.com/2072-6694/18/1/151

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202519213

AI-engineered multifunctional nanoplatforms: synergistically bridging precision diagnosis and intelligent therapy in next-generation oncology https://link.springer.com/article/10.1186/s12951-025-03947-1

Antibody-drug conjugates specifically regulate tumor microenvironment: A promising strategy for pancreatic cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S1499387225002243

Benchmarking Protein Nanoparticles for Drug Delivery and Clinical Translation https://onlinelibrary.wiley.com/doi/10.1002/smtd.202501671

Biology and therapeutic potential of extracellular vesicle targeting and uptake https://www.nature.com/articles/s41580-025-00922-4

ECM-responsive nanomedicine to enhance immunotherapy in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S092777652500863X

Machine learning for nanoparticle-based imaging: From rational design to precision diagnosis https://www.sciencedirect.com/science/article/abs/pii/S0001868625003847

Nanomedicine-mediated modulation of tumor metabolism for enhanced immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925012015

Navigating the Endothelial Barrier: A Multiscale Framework for Precision Nanomedicine https://onlinelibrary.wiley.com/doi/10.1002/smll.202511618

The Biology of Endosomal Escape: Strategies for Enhanced Delivery of Therapeutics https://pubs.acs.org/doi/10.1021/acsnano.5c18112

Advances in Stimuli-Responsive Peptide–Polymer Carriers for Mitochondrial Therapeutics https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c01513

AI and organoid platforms for brain-targeted theranostics https://www.thno.org/v16p0876.htm

Clinical translation of nanomedicines for brain diseases: Current challenges and future directions https://www.sciencedirect.com/science/article/abs/pii/S0168365925010405

Drug delivery systems for mitochondrial targeting https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02199e

Emerging nanoparticle-based therapies for pancreatic cancer: Current clinical landscape https://www.sciencedirect.com/science/article/pii/S0169409X25002455

Engineering complexity into protein-based biomaterials for biomedical applications https://www.nature.com/articles/s41578-025-00861-8

Engineering neural recovery: Micro/nano-structured materials for nerve regeneration https://www.sciencedirect.com/science/article/pii/S2590006425011093

Engineering polymeric micelles for targeted drug delivery: “click” chemistry enabled bioconjugation strategies and emerging applications https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb02193f

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1717062/full

The molecular logic of early metastasis in pancreatic cancer: crosstalk between tumor and microenvironment https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1726581/full

Informing development of brain cancer therapies within “preclinical trials” using ex vivo patient tumors https://www.sciencedirect.com/science/article/pii/S0169409X25002212

Linking nanotechnology and sustainability https://www.nature.com/articles/s41565-025-02105-w

Long-acting lipid-based nanomedicines: rethinking from structure-based rational design to in vivo fate evaluation https://www.sciencedirect.com/science/article/abs/pii/S016836592501079X

Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202416992

Mitochondrial-Based Nanomedicine in Treatment of Liver Cancer https://link.springer.com/article/10.1007/s12033-025-01523-4

Modeling Glioblastoma for Translation: Strengths and Pitfalls of Preclinical Studies https://www.mdpi.com/2079-7737/14/11/1490

Nanomaterial-based therapeutic strategies for spinal cord injury repair: harnessing multifunctionality to overcome pathophysiological challenges https://pubs.rsc.org/en/content/articlelanding/2025/bm/d5bm01238d

Nanomaterials: an overview of current trends and future prospects in neurological disorder treatment https://link.springer.com/article/10.1186/s12967-025-06877-6

Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy https://www.thno.org/v16p1545.htm

Nanomedicines Against Mitochondrial Dysfunction-Induced Metabolic Diseases https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514522

Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy https://link.springer.com/article/10.1007/s12672-025-04088-5

Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma https://www.sciencedirect.com/science/article/pii/S0169409X25002443

Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery https://pubs.rsc.org/en/content/articlelanding/2025/nr/d5nr02259b

Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy https://www.mdpi.com/2072-6694/17/23/3850

Pre-programming the protein corona: From avoidance to endogenous targeting https://www.sciencedirect.com/science/article/abs/pii/S0168365925010612

Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment https://link.springer.com/article/10.1007/s13346-025-02025-1

Recent Advances in Pharmaceutical and Medical Applications in the Area of Selected Porphyrinoids Connected with PLGA or PLGA-Based Modalities https://www.mdpi.com/2073-4360/17/23/3190

Recent advances in potential drug nanocarriers for CNS disorders: a review https://link.springer.com/article/10.1186/s12938-025-01474-6

Reprogramming Immunosuppressive Niches and the Cancer Immunity Cycle in Pancreatic Cancer with Neoantigen mRNA Plus Immune Adjuvant Nanocarrier Strategies https://pubs.acs.org/doi/10.1021/acsnano.5c14753

Targeting MAO offers a novel immunotherapeutic strategy for prostate cancer by modulating the “tumor-stroma-immune” interaction network https://www.sciencedirect.com/science/article/pii/S0304419X25002483

The growing impact of machine learning on drug formulation science https://www.sciencedirect.com/science/article/abs/pii/S0169409X25002467

Tumor microenvironment in glioblastoma: The central role of the hypoxic–necrotic core https://www.sciencedirect.com/science/article/pii/S0304383525007888

Beyond Alzheimer’s disease—translating biomarker insights across CNS diseases https://www.science.org/doi/full/10.1126/scitranslmed.adr2511

Mechanisms of Mitochondrial Transfer Through TNTs: From Organelle Dynamics to Cellular Crosstalk https://www.mdpi.com/1422-0067/26/21/10581

Nanoemulsions as carriers for malignant brain tumors treatment: a scoping review on drugs, natural compounds, and siRNA delivery https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2574249

Advancing glioblastoma therapy with surface-modified nanoparticles https://link.springer.com/article/10.1007/s10072-025-08457-4

Current strategies and novel immunotherapeutic approaches for overcoming immune resistance in glioblastoma https://link.springer.com/article/10.1007/s12672-025-03807-2

Enhanced sonodynamic therapy and theranostic integration for breast cancer treatment: nanomaterial-driven multifunctional platforms https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb01812a

Overcoming standard-of-care resistance in glioblastoma using nanoparticle-based drug delivery targeting the autophagy pathway https://www.sciencedirect.com/science/article/abs/pii/S0006295225005672

PEG alternatives for RNA therapeutics https://www.nature.com/articles/s41563-025-02408-2

Peptide dendrimers: Novel therapeutic opportunities for peptide-based biomaterials in biomedicine https://www.sciencedirect.com/science/article/abs/pii/S0168365925009368

Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers for combination therapy and advanced targeting https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2578376

Targeted immunomodulation for chronic diseases through advanced delivery platforms

https://www.tandfonline.com/doi/full/10.1080/17425247.2025.2580443

The evolution of nanomedicine: The rise of next-generation nanomaterials in cancer nanomedicine https://www.science.org/doi/full/10.1126/sciadv.adx1576

Applying click chemistry principles to the design of tumor-targeted nanosystems https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2567837

Cancer vaccines as enablers of immunotherapy https://www.nature.com/articles/s41590-025-02308-2

Designing around immune memory to counter PEG immunogenicity https://www.nature.com/articles/s41563-025-02383-8