Recently Published Research

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

Amphiphilic Glycopolymer Nanoparticles for pH-Responsive Paclitaxel Delivery and Enhanced Efficacy in Pancreatic Ductal Adenocarcinoma Therapy https://pubs.acs.org/doi/10.1021/acsabm.5c02077

CD98hc controls CNS angiogenesis and blood–brain barrier integrity through localized regulation of the systemic integrin–FAK pathway https://www.nature.com/articles/s44161-026-00816-4

Circular-by-Design Zwitterionic Polyglycerol–Polyoxazoline–Lysine Pseudodendrimers as Multifunctional Antibacterial and Anticancer Drug Delivery Platforms https://pubs.acs.org/doi/abs/10.1021/acs.biomac.6c00382

Decoding collective dynamics and complexity in nanoparticle assemblies using graph theory https://www.science.org/doi/10.1126/science.aeb5134

GSH-responsive triple-action photosensitizer nanoplatforms orchestrate cuproptosis-ferroptosis synergy to potentiate antitumor PDT efficacy https://link.springer.com/article/10.1186/s12951-026-04331-3

High-throughput generation of patient-derived cancer stem cells for precision medicine using a microwell-chip platform https://www.nature.com/articles/s41556-026-01957-1

Multifunctional Nanozyme Hydrogel for Oxidative Stress Scavenging and Mitophagy Activation in Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsami.6c03907

Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury https://pubs.rsc.org/en/content/articlelanding/2026/tb/d6tb00620e

ROS-Responsive Trifluoperazine Prodrug Nanoparticles and Mesenchymal Stem Cell Exosomes Synergistically Modulate Astrocyte Phenotype for Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsami.6c09304

The gut microbiota regulates the protein corona formation, biodistribution, and cellular uptake of lipid nanoparticles https://www.sciencedirect.com/science/article/pii/S0168365926003986

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe https://www.nature.com/articles/s43587-026-01116-z

Advanced Theranostics in a Pancreatic Cancer Model Integrating Dual Optoacoustic-Photodynamic Performance of Asymmetric Zinc Phthalocyanines https://onlinelibrary.wiley.com/doi/10.1002/smll.73557

Covalent functionalization of polymeric nanoparticles prepared from nano-emulsion templates for gene silencing and antioxidant delivery at neuronal level https://www.sciencedirect.com/science/article/abs/pii/S0378517326003662

Expanding the human proteome with microproteins and peptideins https://www.nature.com/articles/s41586-026-10459-x

Generation of two induced pluripotent stem cell lines from patients carrying heterozygous PTEN mutations associated with PTEN Hamartoma Tumor Syndrome https://www.sciencedirect.com/science/article/pii/S1873506126000966

Harnessing genipin as a biocompatible crosslinker in nanomedicine for oncology applications https://link.springer.com/article/10.1007/s13205-026-04791-2

High-throughput human microfluidic organoid-on-a-chip platform for modeling liver diseases and screening nanotherapeutics https://link.springer.com/article/10.1186/s12951-026-04477-0

Intermetallic nanoassemblies potentiate systemic STING activation https://www.science.org/doi/10.1126/science.adx1893

Localized delivery of hyaluronic acid-doxorubicin from a surgical paste for post-operative glioblastoma treatment https://www.sciencedirect.com/science/article/pii/S2590006426003868

Pleiotropic germline PTEN mutations influence gastrulation through dysregulated AKT activation https://www.nature.com/articles/s41525-026-00574-z

Poly-l-lysine integration in PVA hydrogels enables stable, bioactive matrices for motor neuron differentiation and neural network formation https://pubs.rsc.org/en/content/articlelanding/2026/tb/d5tb02475g

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice https://www.science.org/doi/abs/10.1126/scitranslmed.aeb7597

Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment https://www.sciencedirect.com/science/article/pii/S0169409X26001262

3D GelMA–Chitosan constructs regulate mesenchymal stem cell fate via YAP-dependent mechanotransduction for spinal cord injury repair https://journals.sagepub.com/doi/10.1177/08853282261445702

A dual-functional engineered exosome-laden hydrogel redirects endogenous neural stem cell fate for spinal cord injury repair https://www.sciencedirect.com/science/article/pii/S2452199X26001532

A pH-responsive polymeric nanovaccine with efficient endosomal escape and potent antitumor immunity for cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S1742706126002217

Boosting long-term immunity with bioengineered nanovaccines https://www.sciencedirect.com/science/article/abs/pii/S0168365926003263

Condensate corona–nanoparticle complexes transfer functional biomolecules between cells https://www.nature.com/articles/s41563-026-02534-5

Dual-targeting nanoparticles enhance microglial P2Y12R expression to promote neuronal mitophagy for repairing spinal cord injury https://www.nature.com/articles/s41419-026-08596-2

Pathophysiological Protein Corona Governs the Biological Fate of Nanoparticles https://pubs.acs.org/doi/10.1021/acsami.5c23016

Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome https://www.cell.com/iscience/fulltext/S2589-0042(26)00803-5

Spatiotemporal liposome-zwitterionic nano-hydrogel orchestrates immunomodulation and neurogenesis in spinal cord injury repair https://www.sciencedirect.com/science/article/pii/S2590006426003431

Targeted biohybrid nanoplatform for spinal cord injury treatment: Restoring microglial mitophagy and alleviating oxidative stress https://www.sciencedirect.com/science/article/pii/S2590006426003340

The mechanisms and clinical prospects of combining chemotherapy with immunotherapy for advanced pancreatic cancer https://link.springer.com/article/10.1007/s12672-026-05030-z

Biocompatible Nanoparticles Encapsulation of Fluorenyl-Porphyrins: Impact of Arm Structural Modifications on Two-Photon Phototherapeutic Performance https://pubs.acs.org/doi/10.1021/acs.biomac.5c02154

DNA–drug conjugates enable logic-gated drug delivery amplified by hybridization chain reactions https://www.nature.com/articles/s41587-026-03044-0

Whole-body molecular and cellular mapping of the laboratory mouse https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4

Formulation-Driven Control of mRNA Polyplex Physicochemical Properties Enables Spleen-Targeted Systemic Delivery https://pubs.acs.org/doi/10.1021/acsabm.6c00050

Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung https://www.nature.com/articles/s41563-026-02555-0

Osimertinib delivery using 660 nm-activated polymeric nano-photosensitizer carriers for combined photodynamic and EGFR-targeted therapy of non-small cell lung cancer https://www.sciencedirect.com/science/article/abs/pii/S1549963426000419

Mapping cellular heterogeneity and dynamic interactions in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365926001598

Nanovaccines of polydopamine@tumor-associated antigens with robust prophylactic and therapeutic efficacy for cancer immunotherapy https://pubs.rsc.org/en/content/articlelanding/2026/nh/d5nh00681c

Microfluidics-assisted Aprotinin-based nano-carrier for Valproic acid delivery https://www.sciencedirect.com/science/article/abs/pii/S0168365926003123

Self-amplifying nanomedicine reprograms redox metabolism to trigger immunogenic ferroptosis in colon cancer: multiomics identifies AMPD3 as a novel regulator https://www.sciencedirect.com/science/article/abs/pii/S0142961226002206

CD18-targeted peptide-drug conjugate remodels the immunosuppressive tumor microenvironment of prostate cancer by selective depletion of M2 macrophages https://www.nature.com/articles/s41698-026-01377-2

Systemic delivery of drug-free polymeric nanoparticles reprograms innate immunity in a sex-dependent manner after spinal cord injury https://www.biorxiv.org/content/10.64898/2026.03.06.709912v1

A unified biochemical–physical regulatory nanoparticle modulates tumor mechanics to augment nanomedicine penetration and antitumor efficacy https://www.sciencedirect.com/science/article/abs/pii/S0168365926002348

Amino acid composition drives aggregation during peptide synthesis https://www.nature.com/articles/s41557-026-02090-0

Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination https://www.nature.com/articles/s41563-026-02512-x

Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202522617

Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies https://www.science.org/doi/abs/10.1126/scitranslmed.ads9088

Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy https://www.nature.com/articles/s41565-025-02102-z

Smart Macrocycles: Cyclodextrin−Porphyrin Photosensitizers for Photodynamic Therapy in Human Bladder Cancer Cells https://pubs.acs.org/doi/10.1021/acsabm.6c00053

Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel https://www.science.org/doi/full/10.1126/sciadv.adz7615

3D-Printed, Cellulose-Derived Scaffold Promotes Neuroregeneration and Functional Recovery after Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c02180

A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization https://pubs.rsc.org/en/content/articlelanding/2026/ra/d5ra08918b

Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models https://www.science.org/doi/abs/10.1126/scitranslmed.adx4097

AND logic nanoparticle for precision immunotherapy of metastatic cancers https://www.nature.com/articles/s41565-026-02130-3

Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion https://www.science.org/doi/full/10.1126/sciadv.adz1722

Co-delivery nanoparticle targeting CAF for simultaneous activating T cell plus NKT cell attack in solid tumor https://www.sciencedirect.com/science/article/pii/S2090123226002316

Dendritic cell-targeted tumor antigen delivery by glucosylated lipid nanoparticles for precision tumor immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365926000726

Glycosylated Multifunctional Nanoplatform Co-Delivering Artemisinin: Synergizing NIR-Responsive Phototherapy with Chemodynamic Therapy for Precision-Targeted Tumor Theranostics https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202503975

In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery https://www.nature.com/articles/s41587-026-03022-6

Injectable Metal-Free Carbon Dot-Integrated Hydrogel for Regulating Inflammation via Macrophage Metabolic Reprograming in Spinal Cord Injury Therapy https://pubs.acs.org/doi/10.1021/acsnano.5c13627

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy https://www.cell.com/cell/fulltext/S0092-8674(26)00173-X

Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization https://www.nature.com/articles/s41563-026-02519-4

A STING signaling relay from tumor cells to macrophages mediates the improved efficacy of combination chemotherapy in pancreatic cancer https://link.springer.com/article/10.1186/s12929-026-01226-1

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502758

Crosslinking of lipid nanoparticles enhances the delivery efficiency and efficacy of mRNA vaccines https://www.nature.com/articles/s44286-026-00356-5

Extracellular Vesicle-Mediated Precision Delivery of Paclitaxel Activates Mitophagy to Promote Repair after Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsnano.5c21273

In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy https://www.nature.com/articles/s41563-026-02506-9

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature https://www.cell.com/cell/fulltext/S0092-8674(26)00111-X

Matrix Metalloproteinase-Activatable Nanodrug Crossing Blood–Spinal Cord Barrier for On-Demand Drug Release in Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsnano.5c21926

Mitochondria transfer in Glioblastoma https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noag038/8495128

Neonatal Spinal-Cord-Like Scaffold with Hierarchical Structural and Neurogenetic Microenvironments for Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsnano.5c07071

Photo-responsive polyprodrug supramolecular assemblies with self-accelerated subcellular delivery for synergistic photochemotherapy https://www.sciencedirect.com/science/article/abs/pii/S2095927326000034

Photodynamic Therapeutic Monitoring of Glioblastoma Using High-Resolution Photoacoustic Vascular Imaging https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01785

Precancerous niche remodelling dictates nascent tumour persistence https://www.nature.com/articles/s41586-026-10157-8

Protein-based nanocarriers in the management of hard-to-treat solid tumours https://www.sciencedirect.com/science/article/pii/S0169409X26000761

Rescue Radiosensitization of Pancreatic Cancer via PD-L1/TGF-β1 Dual-Blockade Nanotherapy as Evaluated in 3-Dimensional Microtumors https://spj.science.org/doi/10.34133/bmr.0335

Self-amplifying ROS nanorobot with orthogonal NIR activation for enhanced photodynamic–chemodynamic combination therapy https://pubs.rsc.org/en/content/articlelanding/2026/bm/d5bm01705j

Whole-organ and whole-body 3D atlases enable cellome-wide profiling https://www.cell.com/cell/abstract/S0092-8674(25)01507-7

3D-Printed, Cellulose-Derived Scaffold Promotes Neuroregeneration and Functional Recovery after Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c02180

Bioinspired Sericin-PCL Nanoparticles for Sustained Delivery in Cancer with Antioxidant and Antibacterial Efficacies https://link.springer.com/article/10.1007/s12668-026-02436-5

Decellularized Dermis ECM-Based Melanoma-on-a-Chip Model with Integrated Lymphatic and Vascular Networks for High-Throughput Drug Testing https://pubs.acs.org/doi/10.1021/acsabm.5c02329

Injectable ε-poly-lysine/hyaluronic acid hydrogel for targeted prevention of cardiovascular implantable electronic device pocket infections https://pubs.rsc.org/en/content/articlehtml/2026/ra/d5ra08511j

Nanoformulated fingolimod attenuates NLRP3 inflammasome activation and promotes functional recovery in a rat model of spinal cord injury https://www.nature.com/articles/s41393-026-01177-2

Nanovaccines of polydopamine@tumor-associated antigens with robust prophylactic and therapeutic efficacy for cancer immunotherapy https://pubs.rsc.org/en/content/articlelanding/2026/nh/d5nh00681c

Neonatal Spinal-Cord-Like Scaffold with Hierarchical Structural and Neurogenetic Microenvironments for Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsnano.5c07071

Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial https://www.cell.com/cell/abstract/S0092-8674(25)01504-1

Reprogramming the In Vivo Fate of Nanoassemblies: Morphology Regulation to Rod-Like Nanostructures to Enhance Antitumor Efficacy https://pubs.acs.org/doi/10.1021/acsami.5c25772

Selective mRNA Delivery to Activated Macrophages via Hyaluronic Acid-Functionalized Lipid Nanoparticles with Optimized PEGylation https://pubs.acs.org/doi/10.1021/acs.biomac.5c02390

Divergent tumor immunity determined by bacteria-cancer cell engagement https://www.cell.com/cell/abstract/S0092-8674(25)01493-X

Evaluation of PLGA nanoparticle-based conjugate vaccines incorporating lipopolysaccharide and alginate for inducing immunity against P. aeruginosa: a rabbit model study https://www.tandfonline.com/doi/full/10.1080/09205063.2026.2614052

Mitochondrial transfer in the HSC–HCC–macrophage network shapes hepatocellular carcinoma progression https://www.pnas.org/doi/10.1073/pnas.2512592123

Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00455-2

Nanoparticle-Assembled Multifaceted Hydrogel Therapy Promotes Functional Recovery After Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsnano.5c21336

Self-Amplified Nanomedicine Enables Lysosomal Blockade to Potentiate Starvation Therapy of Pancreatic Ductal Adenocarcinoma https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202519523

Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy https://link.springer.com/article/10.1186/s12951-026-04062-5

Translational m-PBPK Modeling reveals active transcytosis as the pivotal mechanism for nanoparticle tumor delivery: Implications for dose optimization https://www.sciencedirect.com/science/article/pii/S0168365926000854

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis https://www.nature.com/articles/s41586-025-10028-8

Machine Learning-Enhanced Engineering of Ultrahigh-Loading Polymer-Drug Assemblies with Programmable ROS-Triggered Release for Tumor Elimination https://www.scilit.com/publications/a705f5b86196fa008acedaa9d1ab9fba

A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma https://www.science.org/doi/full/10.1126/scitranslmed.adt1211

A Patient-Derived Organ-on-Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508934

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery https://www.cell.com/cell/abstract/S0092-8674(25)01434-5

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth https://www.cell.com/cancer-cell/abstract/S1535-6108(25)00555-0

Biomimetic vesicles engineered from modified tumour cells act as personalized vaccines for post-surgical cancer immunotherapy https://www.nature.com/articles/s41565-025-02113-w

DNA nanodevices detect an acidic nanolayer on the lysosomal surface https://www.nature.com/articles/s41556-025-01855-y

Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice https://www.cell.com/cell-host-microbe/abstract/S1931-3128(25)00533-5

Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery https://pubs.acs.org/doi/10.1021/acsnano.5c19431