Recently Published Research

• Dual-Responsive Biomimetic Nanoplatform for Cascade Synergistic Therapy of Endometrial Cancer https://pubs.acs.org/aabmcb/article-abstract/9/17/8030/5253264/Dual-Responsive-Biomimetic-Nanoplatform-for
• A Self-Assembling Janus Dendron-Modified Phthalocyanine Enables Deep Tumor-Targeted Therapy for Gastric Cancer Peritoneal Metastases https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.71702
• A bibliometric analysis of nanoparticle-based therapeutic strategies for pancreatic cancer (2002–2026): Global trends, thematic shifts, and translational frontiers https://www.sciencedirect.com/science/article/abs/pii/S154996342600119X
• Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles https://www.nature.com/articles/s41565-026-02262-6
• Self-oxygenating nanoreactors enable effective low-dose X-ray photodynamic immunotherapy against refractory tumors https://www.sciencedirect.com/science/article/abs/pii/S0142961226006216
• Commensal Nakaseomyces glabratus migrates into prostate tumors to accelerate cancer progression https://www.nature.com/articles/s43018-026-01229-9
• Engineering a Virus-like Nanovaccine for Durable and Potent Antigen-Specific Adoptive Immunity https://pubs.acs.org/jacsat/article-abstract/doi/10.1021/jacs.6c11094/5328233/Engineering-a-Virus-like-Nanovaccine-for-Durable
• A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions https://www.nature.com/articles/s41698-026-01678-6
• A Poly(lactic Acid)-Porphyrin-Cobalt Vaccine Adjuvant System Elicits Protein- or Peptide-Specific Humoral and Cellular Immunity https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.74905
• l-Glutamine in combination with first-line gemcitabine and nab-paclitaxel in advanced pancreatic ductal adenocarcinoma: an open-label, single-arm, phase 1 GlutaPanc trial https://www.nature.com/articles/s43018-026-01225-z
• Localized Prostate Cancer Therapy: Tumor Microenvironment-Activated Spermine Hydrogel With Real-Time Autonomous Fluorescence Sensing https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.71640
• Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis https://www.nature.com/articles/s41556-026-02057-w
• Porphyrin-copper (II) covalent organic framework nanoplatform with intrinsic bifunctional photodynamic and chemodynamic activities for synergistic multimodal cancer therapy https://www.sciencedirect.com/science/article/pii/S2590006426008240
• Solvent Polarity-Directed Morphological Transformation of Zinc Porphyrin Assemblies for Enhanced Photodynamic Therapy of Glioblastoma https://pubs.acs.org/aamick/article-abstract/doi/10.1021/acsami.6c11367/5387104/Solvent-Polarity-Directed-Morphological
• Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis https://www.nature.com/articles/s41588-026-02739-z
• Specific Adsorption of Tumor-Affinity Proteins to Improve Tumor Accumulation for Targeted Imaging and Therapy https://onlinelibrary.wiley.com/doi/10.1002/smll.75585
• Tumor immune microenvironment remodeling predicts response to checkpoint inhibitor therapy https://www.cell.com/cancer-cell/abstract/S1535-6108(26)00384-3
• A CXCR4/PD-L1 Bispecific Nanobody Engineered for Tumor Microenvironment Retention Mediates Sustained Synergy with Chemotherapy via Remodeling Immunity in TNBC https://www.mdpi.com/1424-8247/19/8/1288
• ADA2-Functionalized OMVs Remodel the Tumor Microenvironment in Pancreatic Cancer https://www.mdpi.com/1999-4923/18/8/920
• Chitosan–PEG Nanoparticles for Co-Delivery of Paclitaxel and KRAS G12D-Directed siRNA to Pancreatic Cancer Cells https://www.mdpi.com/1422-0067/27/16/7285
• Cyclopropanol can function as a caged dual-functional warhead for selective electrochemical bioconjugation https://www.nature.com/articles/s41557-026-02227-1
• Development of a mobile high-intensity focused ultrasound platform for preclinical tumor microenvironment modulation in a pancreatic ductal adenocarcinoma mouse model https://www.tandfonline.com/doi/full/10.1080/02656736.2026.2716349
• Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer https://www.nature.com/articles/s41588-026-02714-8
• Hierarchical targeting biomimetic nanoparticles directing to lesion site and mitochondria promote neuroregeneration and attenuate inflammation after spinal cord injury https://www.sciencedirect.com/science/article/pii/S2590006426007891
• Intranasal DNA nanocarrier vaccines with surface-patterned antigens enhance efficacy against respiratory syncytial virus https://www.nature.com/articles/s41563-026-02661-z
• Local delivery of SN-38 for the treatment of glioblastoma: Engineering precision chemotherapy beyond the blood–brain barrier https://www.sciencedirect.com/science/article/abs/pii/S0168365926005298
• Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination https://www.sciencedirect.com/science/article/pii/S014296122600462X
• Macrophage-hitchhiking nanomedicine codelivering gemcitabine and KRAS G12D inhibitor orchestrates chemo-immunotherapy for metastatic colorectal cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365926004487
• Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy https://www.sciencedirect.com/science/article/abs/pii/S0168365926005596
• Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis https://www.science.org/doi/10.1126/science.aeb0054
• Oncogenic Kras targeting with MRTX1133 or Daraxonrasib specifically synergize with anti-CTLA4 to promote anti-tumor immunity in pancreatic cancer https://www.nature.com/articles/s41467-026-75960-3
• Organ-specific colonization and niche remodeling in a human tissue model of metastasis https://www.science.org/doi/abs/10.1126/scitranslmed.adv6871
• Overcoming Barriers in Solid Tumors: Lactate-Fueled Nanomotors Enhance Penetration and Reverse Immunosuppression https://pubs.acs.org/jacsat/article/doi/10.1021/jacs.6c05546/5251888/Overcoming-Barriers-in-Solid-Tumors-Lactate-Fueled
• Overcoming Drug Resistance by Paclitaxel Resistance in Triple-Negative Breast Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.77249
• Proton Sponge-Enabled Dual-Driven Nanomotors for MRI-Guided Tumor-Penetrating Synergistic Therapy of Pancreatic Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.71615
• RVG-Functionalized Liposomal Mollugin: A Targeted Nanotherapy for Spinal Cord Injury https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.71612
• Self-assembled nano-multiple warheads: A precise targeting platform for combinatorial chemotherapy, PTT and PDT therapy against glioma https://www.sciencedirect.com/science/article/abs/pii/S2772950826004322
• Targeted Decationized Polyplexes for siRNA Delivery https://pubs.acs.org/mpohbp/article-abstract/12/1/150/1379233/Targeted-Decationized-Polyplexes-for-siRNA?redirectedFrom=fulltext
• Targeted Lactic Acid Regulation via Engineered Exosomes for Synergistic Metabolic and Photodynamic Tumor Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.71659
• A low-crosslinking hydrogel integrating prodrug nanoparticles modulates neuroinflammation and ECM deposition for enhanced spinal cord regeneration https://www.sciencedirect.com/science/article/abs/pii/S0142961226005508
• Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer https://www.nature.com/articles/s41591-026-04537-w
• An inherent T cell-activating mRNA delivery carrier for in vivo CAR T generation https://www.nature.com/articles/s41563-026-02675-7
• Cascade-Amplifying Immunophototherapy Nanoplatform Integrating Cocktail Drug Delivery https://onlinelibrary.wiley.com/doi/10.1002/smll.75166
• Doxorubicin-Incorporated Nanoparticles Composed of Ce6-Conjugated Hyaluronic Acid-b-poly(ethylene glycol) Copolymer for Overcoming Doxorubicin Resistance of Breast Cancer Cells https://www.mdpi.com/1422-0067/27/15/6993
• Dual-cargo polymeric micelles with tumor-cell/stroma dual-targeting for synergistic eradication of drug-resistant breast cancer https://pubs.rsc.org/bm/article-abstract/doi/10.1039/d6bm00808a/1288809/Dual-cargo-polymeric-micelles-with-tumor-cell
• Hydroxylated poly(amidoamine) dendrimers mediate the co-delivery of proteins and drugs for enhanced neuroprotection against ischemic stroke https://www.sciencedirect.com/science/article/abs/pii/S1742706126005490
• Immunization with mosaic nanoparticles reveals that antigen avidity shapes the clonal hierarchy of the B cell response https://www.science.org/doi/abs/10.1126/scitranslmed.aee5425
• Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy https://www.nature.com/articles/s41565-026-02235-9
• Particle size-dependent efficiency and mechanistic insights of nose-to-brain delivery bypassing the BBB https://www.sciencedirect.com/science/article/abs/pii/S0168365926006589
• Recapitulating In Vivo Pharmacokinetics and Size-Dependent Nanomedicine Delivery in a Microfluidic Platform https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.77137
• Triple-stimuli-responsive and FGL-1-inhibiting polydopamine nanoparticles for synergistic chemo-photothermal immunotherapy of breast cancer https://www.sciencedirect.com/science/article/abs/pii/S0927776526006648
• Ultrasound-guided renal artery administration of angiopoietin-1 RNA therapy slows the progression of preclinical WT1 glomerular disease https://www.science.org/doi/abs/10.1126/scitranslmed.adv1289
• A dependency map enhanced with next-generation 3D cancer models https://www.nature.com/articles/s41586-026-10843-7
• A transferable gut microbiota–bile acid pathway programs nanomedicine pharmacokinetics and therapeutic response https://www.nature.com/articles/s41563-026-02690-8
• A tumour-derived organoid biobank maps cancer gene dependencies https://www.nature.com/articles/s41586-026-10830-y
• A Versatile Tumor Microenvironment-Responsive Nanoprobe for Cancer Screening and Early Detection https://pubs.acs.org/jacsat/article-abstract/148/29/31263/5237481/A-Versatile-Tumor-Microenvironment-Responsive
• An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73878
• Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00661-3
• Dual-Drug Polymer Conjugates of Gemcitabine and Hydroxychloroquine for Pancreatic Cancer: The Critical Role of Linker Chemistry https://pubs.acs.org/aapmcd/article/doi/10.1021/acsapm.6c02161/5236390
• Evaluating the impact of dynamic fluid flow on an advanced model of pancreatic cancer: Towards desmoplasia disruption and chemosensitivity promotion https://www.sciencedirect.com/science/article/pii/S2772950826002827
• Human spinal interneurons repair the injured rat spinal cord through synaptic integration https://www.science.org/doi/abs/10.1126/scitranslmed.aea7461
• Injectable and sprayable supramolecular prodrug hydrogel for long-acting chemo-hormonal therapy of prostate cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365926006243
• Light-responsive polyphosphoester nanocarriers for cascade-amplified synergistic photodynamic-chemotherapy of colon cancer https://www.sciencedirect.com/science/article/abs/pii/S0927776526004455
• Near-infrared light-triggered, self-amplifying targeted drug-delivery platform achieves precision treatment of retinoblastoma https://www.sciencedirect.com/science/article/abs/pii/S0378517326005247
• Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer https://www.nature.com/articles/s41467-026-74334-z
• Redox-responsive polymeric nanocarriers for targeted delivery of bruceantin to pancreatic cancer https://pubs.rsc.org/nr/article-abstract/doi/10.1039/d6nr00636a/1288324/Redox-responsive-polymeric-nanocarriers-for
• Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy https://www.science.org/doi/abs/10.1126/scitranslmed.aeb8054
• Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ https://www.nature.com/articles/s41556-026-02013-8
• Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer https://www.nejm.org/doi/full/10.1056/NEJMoa2605555
• Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing postoperative blood-brain barrier disruption https://www.science.org/doi/abs/10.1126/scitranslmed.adv8761
• A Carrier-Free Peptide Nanomedicine Orchestrates Dual Redox Therapy via Ferroptosis and Disulfidptosis https://pubs.acs.org/aamick/article-abstract/doi/10.1021/acsami.6c08792/5222707/A-Carrier-Free-Peptide-Nanomedicine-Orchestrates
• A multimodal synergistic anti-glioblastoma strategy based on nano-sonodynamic therapy https://pubs.rsc.org/nr/article-abstract/doi/10.1039/d6nr01554a/1281019/A-multimodal-synergistic-anti-glioblastoma
• Catalytic profiling of extracellular vesicles maps altered cancer metabolism https://www.nature.com/articles/s41565-026-02230-0
• Combining an αvβ6-Targeted 177Lu-Based Peptide Receptor Radionuclide Therapy with Olaparib to Boost Therapeutic Efficacy in Pancreatic Cancer https://jnm.snmjournals.org/content/early/2026/07/16/jnumed.125.271137
• Enzymatic degradation of Hyaluronic acid/Poly-l-Lysine capsules for burst drug release https://www.sciencedirect.com/science/article/abs/pii/S0008621526002387
• Immunostimulatory lipogel implant enhances cancer immunotherapy https://www.nature.com/articles/s41565-026-02194-1
• Loading is not delivering: Intracellular drug retention and migration capacity govern macrophage-based drug delivery https://www.science.org/doi/10.1126/sciadv.aec0429
• Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic cancer https://www.nature.com/articles/s41467-026-75883-z
• Thermosensitive Pluronic F127 Micelles for Piperlongumine Delivery: Selective ROS Amplification to Potentiate Cisplatin Efficacy in 3D Lung Cancer Spheroids https://pubs.acs.org/aapmcd/article/doi/10.1021/acsapm.6c01197/5214704/Thermosensitive-Pluronic-F127-Micelles-for
• Tumor-targeted CD40 ligand-functionalized extracellular vesicle mimetics enable chemoimmunotherapy for neuroblastoma https://www.sciencedirect.com/science/article/abs/pii/S0168365926006103
• “Alkaline-Hammer Strategy” Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer https://onlinelibrary.wiley.com/doi/10.1002/anie.8734845
• Dendritic Lipopeptide Nanovaccines Orchestrate Multi-Pattern Recognition Receptors Activation and Potentiate Antitumor Immunity https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73533
• Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers https://pubs.acs.org/doi/10.1021/acs.biomac.6c00159
• EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma https://www.science.org/doi/abs/10.1126/scitranslmed.adx8398
• Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells https://www.nature.com/articles/s41557-026-02195-6
• Long-range extended chains arising from polymerization-driven spontaneous assembly https://www.science.org/doi/10.1126/science.aef1777
• Mechano-reprogramming of tumor-associated macrophages by engineering nanogel stiffness for suppression of tumor development https://link.springer.com/article/10.1186/s12951-026-04793-5
• Mitochondrial complex I inhibition remodels the PDAC fibrotic microenvironment via LOXL2 suppression to potentiate chemo-immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0014299926006230
• Modular in vivo antibody–ADC click to reverse drug resistance in tumours https://www.nature.com/articles/s41586-026-10789-w
• Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers https://www.sciencedirect.com/science/article/pii/S1549963426000882
• Orthogonal Chemistry Enables Precision Nanoparticle Cofunctionalization for Tuning Immune Stimulation and Antigen Presentation https://pubs.acs.org/doi/10.1021/acs.biomac.5c02689
• Rhein-Mn coordination nanomedicine for peritoneal metastatic colorectal cancer: synergistic mitochondrial targeting, immunogenic cell death, and reverses immunosuppression https://link.springer.com/article/10.1186/s12951-026-04556-2
• Thermoresponsive Injectable Self-Healing Hydrogel Loaded with Self-Regenerating Photothermal Agent for Synergistic Photothermal–Thermodynamic–Chemodynamic Therapy for Pancreatic Cancer https://www.mdpi.com/2073-4360/18/13/1620
• Tutorial: strategies for targeting organelles using nanoparticles https://www.nature.com/articles/s41596-026-01401-6
• Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers https://pubs.acs.org/doi/10.1021/acs.biomac.6c00159
• Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells https://www.nature.com/articles/s41557-026-02195-6
• EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma https://www.science.org/doi/abs/10.1126/scitranslmed.adx8398
• Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers https://www.sciencedirect.com/science/article/pii/S1549963426000882
• Long-range extended chains arising from polymerization-driven spontaneous assembly https://www.science.org/doi/10.1126/science.aef1777
• Mechano-reprogramming of tumor-associated macrophages by engineering nanogel stiffness for suppression of tumor development https://link.springer.com/article/10.1186/s12951-026-04793-5
• Dendritic Lipopeptide Nanovaccines Orchestrate Multi-Pattern Recognition Receptors Activation and Potentiate Antitumor Immunity https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73533
• A zinc-coordinated cascade-responsive therapeutic nanoassembly for remodeling the pathological microenvironment and restoring mitochondrial homeostasis in spinal cord injury https://link.springer.com/article/10.1186/s12951-026-04760-0
• An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73878
• Arc mediates intercellular tau transmission via extracellular vesicles https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1
• Biomimetic adhesive hydrogel microcarriers for gas therapy and chemotherapy of gastric cancer https://www.sciencedirect.com/science/article/abs/pii/S1742706126003843
• Chirality-controlled seeded supramolecular polymerization: From glutamide amphiphiles to ultralong helical nanotubes https://www.sciencedirect.com/science/article/abs/pii/S0021979726012142
• Discovery and therapeutic delivery of microRNAs targeting deregulated glioblastoma pathways inhibits tumor growth in mice https://www.jci.org/articles/view/195639
• The intravenous targeted nanopeptide, CAQK, is neuroprotective and improves motor function after spinal cord injury in rats https://journals.lww.com/jtrauma/abstract/9900/the_intravenous_targeted_nanopeptide,_caqk,_is.1429.aspx
• Modulating IL-11-dependent matrix stiffness to delay ovarian aging https://www.nature.com/articles/s43587-026-01159-2
• Opposing intracellular redox modulation by a carrier-free diselenide nanosystem integrates antifibrosis and ferroptosis sensitization for fibrotic pancreatic cancer therapy https://www.sciencedirect.com/science/article/abs/pii/S0142961226004096
• PBAE nanoparticle-mediated delivery of ASCL1 and NGN2 genes for astroglia-to-neuron reprogramming to remodel glial scar for spinal cord injury repair https://link.springer.com/article/10.1186/s13287-026-05159-2
• Size switchable nanomodulator achieving ratio-precise dual-drug codelivery for synergistic glutamine metabolism modulation in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S0142961226004308
• Therapeutic reprogramming of tumour-associated macrophages in pancreatic cancer using a cytotoxic CCR2-targeted nanotheranostic https://link.springer.com/article/10.1186/s12943-026-02597-7