Recently Published Research

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

A pH-responsive liposomal nanoplatform for reprogramming lactate metabolism and immunogenic activation in pancreatic cancer https://www.sciencedirect.com/science/article/pii/S0142961226004254

Cell-Penetrating Peptide Conjugated Polyzwitterion-Drug Enhances Tumor Retention https://pubs.acs.org/doi/10.1021/acs.nanolett.6c01592

High-resolution 3D chromatin maps reveal PTEN enhancer hubs bridged to the promoter through flanking anchors https://www.nature.com/articles/s42003-026-10533-0

Intravenously Delivered Lipid Nanoparticles Access Acute Spinal Cord Injury via Disrupted Vasculature https://www.biorxiv.org/content/10.64898/2026.06.04.730155v1

Matrix Stiffness Directs Stemness Signatures in Breast Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.71371

Amplifying tumour antigen presentations from intratumourally entrapped dendritic cells https://www.nature.com/articles/s41565-026-02204-2

Antibiotic-drug conjugates: Enhancing chemo-immunotherapy of gemcitabine for pancreatic cancer by eliminating intratumoral bacteria https://www.sciencedirect.com/science/article/abs/pii/S0142961226003923

Cellular architecture and neighborhood-informed virtual spatial tumor profiling from histopathology https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8

Efficient prime editing in vivo and in vitro using lipid nanoparticles https://www.nature.com/articles/s41565-026-02200-6

Generation of two induced pluripotent stem cell lines from patients carrying heterozygous PTEN mutations associated with PTEN Hamartoma Tumor Syndrome https://www.sciencedirect.com/science/article/pii/S1873506126000966

Inhalable viromimetic polymer nanoparticle vaccine (iVPNVax) in a subcutaneous-prime/inhalation-boost vaccination schedule for eliciting durable mucosal and systemic immune protection https://pubs.rsc.org/en/content/articlelanding/2026/bm/d6bm00350h

Integrated top-down and bottom-up proteomics enables precise characterization of proteoforms within the protein corona https://www.nature.com/articles/s41467-026-74306-3

Intercepting YAP Activation in Prostate Cancer Blocks Neuroendocrine Progression https://aacrjournals.org/cancerres/article-abstract/86/12/2860/785620/Intercepting-YAP-Activation-in-Prostate-Cancer

Nano-enabled spatially selective protein degradation modulates lactate metabolism to potentiate antitumor immunity in liver cancer https://www.nature.com/articles/s41565-026-02196-z

Nanoparticles reach metastatic tumours via enhanced permeability of adjacent vessels https://www.nature.com/articles/s41565-026-02171-8

Optimizing intravenous solid tumour treatment through active targeting approaches and polymeric micelles engineering: A meta-analysis in mouse models https://www.sciencedirect.com/science/article/pii/S0168365926005067

PLGA/PVA nanoparticles to deliver a protein-based cancer vaccine targeting GPC1 for the treatment of pancreatic ductal adenocarcinoma https://www.tandfonline.com/doi/full/10.1080/17435889.2026.2676617

POLY-Senolytic nanoplatform for tumor-specific eradication of senescent tumor cells and mitigation of radiotherapy-induced immune resistance of cancer https://www.nature.com/articles/s41467-026-73109-w

Precision-engineered STING agonist nanoparticles enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection https://www.nature.com/articles/s41565-026-02188-z

Programmable nanocarriers with reversible ligand shielding and acid-triggered burst release for sequential tumor penetration and intracellular drug delivery https://www.sciencedirect.com/science/article/abs/pii/S0927776526005011

Programmed oral delivery of peptide therapeutics for multiorgan targeting in metabolic disorders of hyperglycemia and hyperuricemia https://www.science.org/doi/full/10.1126/sciadv.aef3323

Spatiotemporally controlled depletion of efflux-dominant cells enhances intratumoral delivery of nanomedicines https://www.sciencedirect.com/science/article/pii/S154996342600081X

Synergistic Thermochemotherapy via Injectable Polyurethane Hydrogel Co-Delivering Cisplatin and 17AAG for Peritoneal Metastasis of Colorectal Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202504662

Targeted polymeric nanoparticles enable epithelial translocation of PROTACs and preserve intracellular protein degradation activity https://www.sciencedirect.com/science/article/pii/S0928098726001612

Tumor Microenvironment-Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76146

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance https://www.pnas.org/doi/10.1073/pnas.2610708123

Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine https://www.science.org/doi/full/10.1126/sciadv.aea5433

Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing https://www.nature.com/articles/s41467-026-73512-3

Dual-Targeting iRGD-Functionalized Pentablock Copolymer Nanosystem for miR-345-5p and Gemcitabine Delivery to Pancreatic Tumors https://pubs.acs.org/doi/10.1021/acsami.5c25021

Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts https://www.nature.com/articles/s41563-026-02615-5

Long-range extended chains arising from polymerization-driven spontaneous assembly https://www.science.org/doi/10.1126/science.aef1777

Magnetoelectric microrobots for spinal cord injury regeneration https://www.nature.com/articles/s41563-026-02625-3

Nanoparticle modulation of immune and vascular microenvironment dynamics following spinal cord injury https://www.jneurosci.org/content/early/2026/06/03/JNEUROSCI.2177-25.2026

Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors https://www.nature.com/articles/s41587-026-03152-x

Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer https://www.nature.com/articles/s41392-026-02685-6

The influence of structural diversity in polymer-based nanomedicines on anti-cancer efficacy https://www.sciencedirect.com/science/article/pii/S0168365926004669

A Structurally Stabilized Lipopolymer Nanoplatform Targeting Pan-Tissue Antigen-Presenting Cells Enables Durable in situ mRNA Cancer Immunotherapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202520594

Arginine Polymer-Based Nanoplatform Facilitates Oral Co-Delivery of Antibody/Antigen for Robust Oral Immunotherapy in Orthotopic Colon Cancer https://pubs.acs.org/doi/10.1021/acsnano.6c08006

Biofabricated Alginate Hydrogels to Study Prostate Tumoral Microenvironments In Vitro https://pubs.acs.org/doi/10.1021/acsomega.5c13436

Combating small extracellular vesicle–mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides https://www.nature.com/articles/s41392-026-02736-y

Convergence of high throughput experimentation and machine learning to rapidly advance application-specific polymer development https://pubs.rsc.org/en/content/articlelanding/2026/lp/d5lp00380f

Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer https://www.nejm.org/doi/full/10.1056/NEJMoa2605555

Differential assembly of mouse and human tumor microenvironments https://www.nature.com/articles/s41590-026-02505-7

Dual-Targeting iRGD-Functionalized Pentablock Copolymer Nanosystem for miR-345-5p and Gemcitabine Delivery to Pancreatic Tumors https://pubs.acs.org/doi/10.1021/acsami.5c25021

Enhancing antitumour nanovaccine efficacy via integrated cholesterol modulation in situ https://www.nature.com/articles/s41565-026-02153-w

Inhalable Polymeric Nanoparticle Vaccine for Lysosome-Targeting Co-Delivery of Antigen and Adjuvant With Enhanced Immunoprotection https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73112

MitoPG: An engineered biocompatible nanocarrier for drug delivery to neuronal mitochondria https://www.sciencedirect.com/science/article/abs/pii/S1549963426000602

Multitargeted nanoparticles inhibit cancer invasion by disrupting cancer-associated fibroblast-tumor cell crosstalk and modulating collagen pattern and EMT https://link.springer.com/article/10.1186/s12951-026-04526-8

Poly-l-lysine integration in PVA hydrogels enables stable, bioactive matrices for motor neuron differentiation and neural network formation https://pubs.rsc.org/en/content/articlelanding/2026/tb/d5tb02475g

Senescent Cell Derived Artificial Vesicle-Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross-Presentation Efficacy https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.75770

Amphiphilic Glycopolymer Nanoparticles for pH-Responsive Paclitaxel Delivery and Enhanced Efficacy in Pancreatic Ductal Adenocarcinoma Therapy https://pubs.acs.org/doi/10.1021/acsabm.5c02077

CD98hc controls CNS angiogenesis and blood–brain barrier integrity through localized regulation of the systemic integrin–FAK pathway https://www.nature.com/articles/s44161-026-00816-4

Circular-by-Design Zwitterionic Polyglycerol–Polyoxazoline–Lysine Pseudodendrimers as Multifunctional Antibacterial and Anticancer Drug Delivery Platforms https://pubs.acs.org/doi/abs/10.1021/acs.biomac.6c00382

Decoding collective dynamics and complexity in nanoparticle assemblies using graph theory https://www.science.org/doi/10.1126/science.aeb5134

GSH-responsive triple-action photosensitizer nanoplatforms orchestrate cuproptosis-ferroptosis synergy to potentiate antitumor PDT efficacy https://link.springer.com/article/10.1186/s12951-026-04331-3

High-throughput generation of patient-derived cancer stem cells for precision medicine using a microwell-chip platform https://www.nature.com/articles/s41556-026-01957-1

Multifunctional Nanozyme Hydrogel for Oxidative Stress Scavenging and Mitophagy Activation in Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsami.6c03907

Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury https://pubs.rsc.org/en/content/articlelanding/2026/tb/d6tb00620e

ROS-Responsive Trifluoperazine Prodrug Nanoparticles and Mesenchymal Stem Cell Exosomes Synergistically Modulate Astrocyte Phenotype for Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsami.6c09304

The gut microbiota regulates the protein corona formation, biodistribution, and cellular uptake of lipid nanoparticles https://www.sciencedirect.com/science/article/pii/S0168365926003986

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe https://www.nature.com/articles/s43587-026-01116-z

Advanced Theranostics in a Pancreatic Cancer Model Integrating Dual Optoacoustic-Photodynamic Performance of Asymmetric Zinc Phthalocyanines https://onlinelibrary.wiley.com/doi/10.1002/smll.73557

Covalent functionalization of polymeric nanoparticles prepared from nano-emulsion templates for gene silencing and antioxidant delivery at neuronal level https://www.sciencedirect.com/science/article/abs/pii/S0378517326003662

Expanding the human proteome with microproteins and peptideins https://www.nature.com/articles/s41586-026-10459-x

Generation of two induced pluripotent stem cell lines from patients carrying heterozygous PTEN mutations associated with PTEN Hamartoma Tumor Syndrome https://www.sciencedirect.com/science/article/pii/S1873506126000966

Harnessing genipin as a biocompatible crosslinker in nanomedicine for oncology applications https://link.springer.com/article/10.1007/s13205-026-04791-2

High-throughput human microfluidic organoid-on-a-chip platform for modeling liver diseases and screening nanotherapeutics https://link.springer.com/article/10.1186/s12951-026-04477-0

Intermetallic nanoassemblies potentiate systemic STING activation https://www.science.org/doi/10.1126/science.adx1893

Localized delivery of hyaluronic acid-doxorubicin from a surgical paste for post-operative glioblastoma treatment https://www.sciencedirect.com/science/article/pii/S2590006426003868

Pleiotropic germline PTEN mutations influence gastrulation through dysregulated AKT activation https://www.nature.com/articles/s41525-026-00574-z

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice https://www.science.org/doi/abs/10.1126/scitranslmed.aeb7597

Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment https://www.sciencedirect.com/science/article/pii/S0169409X26001262

3D GelMA–Chitosan constructs regulate mesenchymal stem cell fate via YAP-dependent mechanotransduction for spinal cord injury repair https://journals.sagepub.com/doi/10.1177/08853282261445702

A dual-functional engineered exosome-laden hydrogel redirects endogenous neural stem cell fate for spinal cord injury repair https://www.sciencedirect.com/science/article/pii/S2452199X26001532

A pH-responsive polymeric nanovaccine with efficient endosomal escape and potent antitumor immunity for cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S1742706126002217

Boosting long-term immunity with bioengineered nanovaccines https://www.sciencedirect.com/science/article/abs/pii/S0168365926003263

Condensate corona–nanoparticle complexes transfer functional biomolecules between cells https://www.nature.com/articles/s41563-026-02534-5

Dual-targeting nanoparticles enhance microglial P2Y12R expression to promote neuronal mitophagy for repairing spinal cord injury https://www.nature.com/articles/s41419-026-08596-2

Pathophysiological Protein Corona Governs the Biological Fate of Nanoparticles https://pubs.acs.org/doi/10.1021/acsami.5c23016

Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome https://www.cell.com/iscience/fulltext/S2589-0042(26)00803-5

Spatiotemporal liposome-zwitterionic nano-hydrogel orchestrates immunomodulation and neurogenesis in spinal cord injury repair https://www.sciencedirect.com/science/article/pii/S2590006426003431

Targeted biohybrid nanoplatform for spinal cord injury treatment: Restoring microglial mitophagy and alleviating oxidative stress https://www.sciencedirect.com/science/article/pii/S2590006426003340

The mechanisms and clinical prospects of combining chemotherapy with immunotherapy for advanced pancreatic cancer https://link.springer.com/article/10.1007/s12672-026-05030-z

Biocompatible Nanoparticles Encapsulation of Fluorenyl-Porphyrins: Impact of Arm Structural Modifications on Two-Photon Phototherapeutic Performance https://pubs.acs.org/doi/10.1021/acs.biomac.5c02154

DNA–drug conjugates enable logic-gated drug delivery amplified by hybridization chain reactions https://www.nature.com/articles/s41587-026-03044-0

Whole-body molecular and cellular mapping of the laboratory mouse https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4

Formulation-Driven Control of mRNA Polyplex Physicochemical Properties Enables Spleen-Targeted Systemic Delivery https://pubs.acs.org/doi/10.1021/acsabm.6c00050

Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung https://www.nature.com/articles/s41563-026-02555-0

Osimertinib delivery using 660 nm-activated polymeric nano-photosensitizer carriers for combined photodynamic and EGFR-targeted therapy of non-small cell lung cancer https://www.sciencedirect.com/science/article/abs/pii/S1549963426000419

Mapping cellular heterogeneity and dynamic interactions in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365926001598

Nanovaccines of polydopamine@tumor-associated antigens with robust prophylactic and therapeutic efficacy for cancer immunotherapy https://pubs.rsc.org/en/content/articlelanding/2026/nh/d5nh00681c

Microfluidics-assisted Aprotinin-based nano-carrier for Valproic acid delivery https://www.sciencedirect.com/science/article/abs/pii/S0168365926003123

Self-amplifying nanomedicine reprograms redox metabolism to trigger immunogenic ferroptosis in colon cancer: multiomics identifies AMPD3 as a novel regulator https://www.sciencedirect.com/science/article/abs/pii/S0142961226002206

CD18-targeted peptide-drug conjugate remodels the immunosuppressive tumor microenvironment of prostate cancer by selective depletion of M2 macrophages https://www.nature.com/articles/s41698-026-01377-2

Systemic delivery of drug-free polymeric nanoparticles reprograms innate immunity in a sex-dependent manner after spinal cord injury https://www.biorxiv.org/content/10.64898/2026.03.06.709912v1

A unified biochemical–physical regulatory nanoparticle modulates tumor mechanics to augment nanomedicine penetration and antitumor efficacy https://www.sciencedirect.com/science/article/abs/pii/S0168365926002348

Amino acid composition drives aggregation during peptide synthesis https://www.nature.com/articles/s41557-026-02090-0

Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination https://www.nature.com/articles/s41563-026-02512-x

Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202522617

Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies https://www.science.org/doi/abs/10.1126/scitranslmed.ads9088

Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy https://www.nature.com/articles/s41565-025-02102-z

Smart Macrocycles: Cyclodextrin−Porphyrin Photosensitizers for Photodynamic Therapy in Human Bladder Cancer Cells https://pubs.acs.org/doi/10.1021/acsabm.6c00053

Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel https://www.science.org/doi/full/10.1126/sciadv.adz7615