Recently Published Research

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

Remodeling tumor microenvironment by versatile nanoplatform orchestrated mechanotherapy with chemoimmunotherapy to synergistically enhance anticancer efficiency https://www.sciencedirect.com/science/article/abs/pii/S0142961225000237

Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors https://pubs.acs.org/doi/10.1021/acsnano.4c12808

Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer https://pubs.acs.org/doi/10.1021/acsnano.4c18489

Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma https://www.science.org/doi/full/10.1126/sciadv.adr8841

A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro https://www.science.org/doi/10.1126/sciadv.adq2616

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy https://www.nature.com/articles/s41587-024-02490-y

Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine https://www.nature.com/articles/s41467-024-54963-y

Evolution of myeloid-mediated immunotherapy resistance in prostate cancer https://www.nature.com/articles/s41586-024-08290-3

Improved Control of Triple-Negative Breast Cancer Tumor and Metastasis with a pH-Sensitive Hyaluronic Acid Nanocarrier for Doxorubicin Delivery https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c01485

Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy https://pubs.acs.org/doi/10.1021/acsami.4c16837

Peptide Nanocarriers for Targeted Delivery of Nucleic Acids for Cancer Therapy https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00324

pH-Responsive Polyethylene Glycol Engagers for Enhanced Brain Delivery of PEGylated Nanomedicine to Treat Glioblastoma https://pubs.acs.org/doi/10.1021/acsnano.4c05906

Porphyrin–Camptothecin (CPT) Grafted Polyoxazoline Amphiphiles for Tumor Photodynamic–Chemotherapy Combination Treatment https://pubs.acs.org/doi/10.1021/acsami.4c17267

Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system https://www.nature.com/articles/s41587-024-02487-7

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity https://www.sciencedirect.com/science/article/abs/pii/S1535610824004021

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma https://www.nature.com/articles/s41586-024-08224-z

Enhancing localized chemotherapy with anti-angiogenesis and nanomedicine synergy for improved tumor penetration in well-vascularized tumors https://www.nature.com/articles/s41540-024-00467-w

Elucidating acquired PARP inhibitor resistance in advanced prostate cancer https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00403-3

Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes https://www.nature.com/articles/s41565-024-01785-0

In vitro drug testing using patient-derived ovarian cancer organoids https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-024-01520-2

Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy https://www.nature.com/articles/s41467-024-53010-0

Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00314-3

Designed endocytosis-inducing proteins degrade targets and amplify signals https://www.nature.com/articles/s41586-024-07948-2

Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00314-3

Pluronic F127-Complexed PEGylated Poly(glutamic acid)-Cisplatin Nanomedicine for Enhanced Glioblastoma Therapy https://onlinelibrary.wiley.com/doi/10.1002/marc.202400662

Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy https://www.cell.com/cell/abstract/S0092-8674(24)00904-8

Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery https://www.nature.com/articles/s41563-024-01961-6

Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics https://www.nature.com/articles/s41565-024-01757-4

Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models https://www.sciencedirect.com/science/article/pii/S0168365924005546

Acid-degradable lipid nanoparticles enhance the delivery of mRNA https://www.nature.com/articles/s41565-024-01765-4

Mitigating the Effects of Persistent Antipolymer Immune Reactions in Nanomedicine: Evaluating Materials-Based Approaches Using Molecular Imaging https://pubs.acs.org/doi/abs/10.1021/acsnano.4c07317

Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) https://pubs.acs.org/doi/10.1021/acsmacrolett.4c00400

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity https://www.nature.com/articles/s41587-024-02301-4

Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids https://www.nature.com/articles/s41563-024-01908-x

Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer https://www.nature.com/articles/s41591-024-03075-7

Active control of pharmacokinetics using light-responsive polymer-drug conjugates for boron neutron capture therapy https://www.sciencedirect.com/science/article/pii/S0168365924003493

Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis https://www.science.org/doi/full/10.1126/sciadv.adn6157

Biointerface-Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment https://onlinelibrary.wiley.com/doi/10.1002/adma.202401495

Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing https://www.science.org/doi/full/10.1126/sciadv.adn2332

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment https://www.sciencedirect.com/science/article/abs/pii/S0168365924003559

Fifty years of sciences with Patrick Couvreur https://link.springer.com/article/10.1007/s13346-024-01643-5

Mitochondria-targeted polyprodrug nanoparticles induce mitochondrial stress for immunogenic chemo-photodynamic therapy of ovarian cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365924003560

Sorafenib Encapsulated Poly(ester amide) Nanoparticles for Efficient and Biosafe Prostate Cancer Therapy https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c00345

Synthetic genomic nanomedicine with triple-responsiveness for systemic anti-tumor therapy https://www.sciencedirect.com/science/article/abs/pii/S0021979724012505

Toward an international standardisation roadmap for nanomedicine https://link.springer.com/article/10.1007/s13346-024-01646-2

Particle uptake in cancer cells can predict malignancy and drug resistance using machine learning https://www.science.org/doi/full/10.1126/sciadv.adj4370

Enhanced Tumor Site Accumulation and Therapeutic Efficacy of Extracellular Matrix-Drug Conjugates Targeting Tumor Cells https://onlinelibrary.wiley.com/doi/10.1002/smll.202402040

Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles https://www.science.org/doi/full/10.1126/sciadv.adk9996

A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research https://www.nature.com/articles/s41565-024-01673-7

A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson’s disease–associated glial changes https://www.nature.com/articles/s43587-024-00583-6

Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00145-0

Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys https://www.nature.com/articles/s41467-024-48442-7

Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids https://www.cell.com/cell-stem-cell/abstract/S1934-5909(24)00146-2

Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure https://www.science.org/doi/10.1126/sciadv.adk4492

Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer https://onlinelibrary.wiley.com/doi/10.1002/adhm.202304618

Supramolecular Assembly and Thermogelation Strategies Using Peptide–Polymer Conjugates https://pubs.acs.org/doi/abs/10.1021/acs.biomac.4c00031

hermoresponsive Core-cross-linked Nanoparticles from HA-b-ELP Diblock Copolymers https://pubs.acs.org/doi/abs/10.1021/acs.biomac.4c00137

Thermosensitive polymer prodrug nanoparticles prepared by an all-aqueous nanoprecipitation process and application to combination therapy https://www.sciencedirect.com/science/article/pii/S0168365924002104

Reexamining in vivo fate of paclitaxel-loaded polymeric micelles https://www.sciencedirect.com/science/article/abs/pii/S1748013224001105

Dual-Responsive Nanomedicine Activates Programmed Antitumor Immunity through Targeting Lymphatic System https://pubs.acs.org/doi/10.1021/acsnano.3c11464

A quantitative MRI-based approach to estimate the permeation and retention of nanomedicines in tumors https://www.sciencedirect.com/science/article/pii/S0168365924001718

Advancements in Nanoparticle Characterization https://link.springer.com/protocol/10.1007/978-1-0716-3786-9_1

Amino-Acid-Encoded Bioinspired Supramolecular Self-Assembly of Multimorphological Nanocarriers https://onlinelibrary.wiley.com/doi/10.1002/smll.202311351

Antiangiogenic Therapeutic mRNA Delivery Using Lung-Selective Polymeric Nanomedicine for Lung Cancer Treatment https://pubs.acs.org/doi/10.1021/acsnano.3c13039

Blood–Brain Barrier Penetrating Nanovehicles for Interfering with Mitochondrial Electron Flow in Glioblastoma https://pubs.acs.org/doi/10.1021/acsnano.3c12434

Dendritic Polymer-Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Anti-Tumor Immune Response https://onlinelibrary.wiley.com/doi/10.1002/adma.202401304

Dendronized Polymer-Derived Nanomedicines for Mitochondrial Dynamics Regulation and Immune Modulation https://onlinelibrary.wiley.com/doi/10.1002/adma.202400582

Engineering Mesoscopic 3D Tumor Models with a Self-Organizing Vascularized Matrix https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202303196

Free PEG Suppresses Anaphylaxis to PEGylated Nanomedicine in Swine https://pubs.acs.org/doi/10.1021/acsnano.3c11165

Glycocalyx-Mimicking Nanoparticles with Differential Organ Selectivity for Drug Delivery and Therapy https://onlinelibrary.wiley.com/doi/10.1002/adma.202311283

Nanobody-mediated targeting of zinc phthalocyanine with polymer micelles as nanocarriers https://www.sciencedirect.com/science/article/pii/S0378517324002382

Nanoparticle-Catalyzed Transamination under Tumor Microenvironment Conditions: A Novel Tool to Disrupt the Pool of Amino Acids and GSSG in Cancer Cells https://pubs.acs.org/doi/10.1021/acs.nanolett.3c04947

Multiparametric in vitro and in vivo analysis of the safety profile of self-assembling peptides https://www.nature.com/articles/s41598-024-54051-7

Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity https://onlinelibrary.wiley.com/doi/10.1002/anie.202317817

Personalized Versus Precision Nanomedicine for Treatment of Ovarian Cancer https://onlinelibrary.wiley.com/doi/10.1002/smll.202307462

An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids https://pubs.acs.org/doi/10.1021/acsnano.3c09027

Full-length single-molecule protein fingerprinting https://www.nature.com/articles/s41565-023-01598-7

Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker https://www.sciencedirect.com/science/article/abs/pii/S0168365924000373

Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition https://www.nature.com/articles/s41587-023-02099-7

Biomimetic bright optotheranostics for metastasis monitoring and multimodal image-guided breast cancer therapeutics https://www.sciencedirect.com/science/article/pii/S0168365924000713

Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy https://www.nature.com/articles/s41467-024-44963-3

Differentiating enantiomers by directional rotation of ions in a mass spectrometer https://www.science.org/doi/10.1126/science.adj8342

E-selectin-targeted polymer-doxorubicin conjugate induces regression of established colorectal liver metastases and improves mice survival https://www.sciencedirect.com/science/article/abs/pii/S1748013224000379

Urease-powered nanobots for radionuclide bladder cancer therapy https://www.nature.com/articles/s41565-023-01577-y

Synthesis of Thermo-Responsive Monofunctionalized Diblock Copolymer Worms https://www.mdpi.com/2073-4360/15/23/4590

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective https://www.cell.com/cell/fulltext/S0092-8674(23)01345-4

Simulation of transvascular transport of nanoparticles in tumor microenvironments for drug delivery applications https://www.nature.com/articles/s41598-024-52292-0

Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders https://www.nature.com/articles/s41556-023-01339-x

Single-particle imaging of nanomedicine entering the brain https://www.pnas.org/doi/10.1073/pnas.2309811121

Probing the chemical ‘reactome’ with high-throughput experimentation data https://www.nature.com/articles/s41557-023-01393-w

Site-specific controlled-release nanoparticles for immune reprogramming via dual metabolic inhibition against triple-negative breast cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365923008064

A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells https://www.sciencedirect.com/science/article/pii/S1742706124000023

Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines https://www.sciencedirect.com/science/article/pii/S001430572400017X

Toward the Scalable, Rapid, Reproducible, and Cost-Effective Synthesis of Personalized Nanomedicines at the Point of Care https://pubs.acs.org/doi/10.1021/acs.nanolett.3c04171

Glutamate affects self-assembly, protein corona, and anti-4 T1 tumor effects of melittin/vitamin E-succinic acid-(glutamate)n nanoparticles https://www.sciencedirect.com/science/article/abs/pii/S0168365923007976

Enhanced chemotherapy and anti-metastasis with in situ nanosphere-to-nanofiber transition https://www.sciencedirect.com/science/article/abs/pii/S1748013223003717

Preparation of trastuzumab-DM1 conjugate with a high drug-to-antibody ratio for breast cancer therapy https://www.sciencedirect.com/science/article/abs/pii/S1748013223003833

Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation https://www.sciencedirect.com/science/article/pii/S1549963423000813

A polymeric nanocarrier that eradicates breast cancer stem cells and delivers chemotherapeutic drugs
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-023-00465-9

Chimeric Peptide-Engineered Self-Delivery Nanomedicine for Photodynamic-Triggered Breast Cancer Immunotherapy by Macrophage Polarization https://onlinelibrary.wiley.com/doi/10.1002/smll.202309994

Exploration of a Pretargeted Theranostic Copolymer Employing Inverse Electron-Demand Diels–Alder Conjugation in Ovarian Cancer https://pubs.acs.org/doi/abs/10.1021/acsapm.3c01849

Impact of the physical-chemical properties of poly(lactic acid)–poly(ethylene glycol) polymeric nanoparticles on biodistribution https://www.sciencedirect.com/science/article/abs/pii/S0168365923007605

Microfluidics-Prepared Ultra-small Biomimetic Nanovesicles for Brain Tumor Targeting https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202302302

Poly(lactic-co-glycolic) acid nanoparticles localize in vesicles after diffusing into cells and are retained by intracellular traffic modulators https://www.futuremedicine.com/doi/full/10.2217/nnm-2023-0139

In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells https://www.nature.com/articles/s41596-023-00902-y

A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer https://www.nature.com/articles/s41591-023-02643-7

Optical sequencing of single synthetic polymers https://www.nature.com/articles/s41557-023-01363-2

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance https://pubs.acs.org/doi/10.1021/acsnano.3c05853

DrugGPT: A GPT-based Strategy for Designing Potential Ligands Targeting Specific Proteins https://www.biorxiv.org/content/10.1101/2023.06.29.543848v1.full

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma https://www.science.org/doi/abs/10.1126/scitranslmed.adi1617

A facile, flexible, and multifunctional thermo-chemotherapy system for customized treatment of drug-resistant breast cancer https://www.sciencedirect.com/science/article/pii/S0168365923006600

Differential cellular responses to FDA-approved nanomedicines: an exploration of albumin-based nanocarriers and liposomes in protein corona formation https://pubs.rsc.org/en/content/articlelanding/2023/nr/d3nr04862d

Immunoregulatory liposomes hitchhiking on neutrophils for enhanced carbon ion radiotherapy-assisted immunotherapy of glioblastoma https://www.sciencedirect.com/science/article/abs/pii/S1748013223002864

Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins https://www.nature.com/articles/s41565-023-01514-z

Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma https://link.springer.com/article/10.1007/s13346-023-01456-y

Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice https://pubs.acs.org/doi/10.1021/acsnano.3c04037

Proteomics reveals time-dependent protein corona changes in the intracellular pathway https://www.sciencedirect.com/science/article/pii/S1742706123006104

Mitochondrial-targeted brequinar liposome boosted mitochondrial-related ferroptosis for promoting checkpoint blockade immunotherapy in bladder cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365923006119

Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging https://www.thno.org/v13p4952

Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients https://www.sciencedirect.com/science/article/abs/pii/S0168365923005898

Palbociclib releases the latent differentiation capacity of neuroblastoma cells https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00443-4

Efficacy comparisons of solvent-based paclitaxel, liposomal paclitaxel, nanoparticle albumin-bound paclitaxel, and docetaxel after neoadjuvant systemic treatment in breast cancer https://www.sciencedirect.com/science/article/abs/pii/S1549963423000588

In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity https://www.nature.com/articles/s41563-023-01646-6

Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours https://www.nature.com/articles/s41565-023-01498-w

Conjugation Length-Dependent Raman Scattering Intensity of Conjugated Polymers https://onlinelibrary.wiley.com/doi/10.1002/marc.202300412

An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice https://www.sciencedirect.com/science/article/pii/S0168365923004649

Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365923005321

Spatiotemporally-Programmed Dual-Acid-Sensitive Nanoworms of Albumin-Poly(tertiary amine)-Doxorubicin Conjugates for Enhanced Cancer Chemotherapy https://onlinelibrary.wiley.com/doi/10.1002/adhm.202301890

Nanoparticles that target the mitochondria of tumor cells to restore oxygen supply for photodynamic therapy: Design and preclinical validation against breast cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365923004881

Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202102441

Tuning Polymer Composition Leads to Activity–Stability Tradeoff in Enzyme-Polymer Conjugates https://pubs.acs.org/doi/abs/10.1021/acs.biomac.3c00396

PEG2000-PLA-based nanoscale polymeric micelles reduce paclitaxel-related toxicity in beagle dogs https://www.sciencedirect.com/science/article/abs/pii/S0168365923005515

Dendritic polymer-functionalized nanomedicine potentiates immunotherapy via lethal energy crisis-induced PD-L1 degradation https://www.sciencedirect.com/science/article/abs/pii/S0142961223003022

Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365923005321

Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium vivax https://www.sciencedirect.com/science/article/pii/S0168365923005059

Enhancing chemotherapy for pancreatic cancer through efficient and sustained tumor microenvironment remodeling with a fibroblast-targeted nanosystem https://www.sciencedirect.com/science/article/abs/pii/S0168365923004856

Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination https://www.science.org/doi/abs/10.1126/scitranslmed.abq0603

Stimuli-responsive self-assembled polymer nanoparticles for the oral delivery of antibodies https://www.sciencedirect.com/science/article/abs/pii/S0168365923004686

The exit of nanoparticles from solid tumours https://www.nature.com/articles/s41563-023-01630-0

Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona https://www.nature.com/articles/s41565-023-01455-7

On-chip modeling of physiological and pathological blood-brain barrier microenvironment for studying glial responses to neuroinflammation https://www.sciencedirect.com/science/article/abs/pii/S1748013223001962

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles https://www.nature.com/articles/s41467-023-40453-0

Rational nanoparticle design: Optimization using insights from experiments and mathematical models https://www.sciencedirect.com/science/article/abs/pii/S0168365923004418

Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response https://www.science.org/doi/full/10.1126/sciadv.add9871

Tuning the Cross-Linking Density and Cross-Linker in Core Cross-Linked Polymeric Micelles and Its Effects on the Particle Stability in Human Blood Plasma and Mice https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c00308

Prediction of cancer nanomedicines self-assembled from meta-synergistic drug pairs https://www.sciencedirect.com/science/article/abs/pii/S0168365923004236

Peptide Self-Assembly Controlled Photoligation of Polymers https://pubs.acs.org/doi/abs/10.1021/jacs.3c03961

Overcoming the blood-brain barrier? – prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models https://www.sciencedirect.com/science/article/abs/pii/S0168365923004431

Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route https://www.sciencedirect.com/science/article/abs/pii/S0168365923004005

Identification of the Proteins Determining the Blood Circulation Time of Nanoparticles https://pubs.acs.org/doi/10.1021/acsnano.3c02041

In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy https://onlinelibrary.wiley.com/doi/10.1002/anie.202308413

Long-acting refillable nanofluidic implant confers protection against SHIV infection in nonhuman primates https://www.science.org/doi/10.1126/scitranslmed.adg2887

Nanoparticles Hitchhike on Monocytes for Glioblastoma Treatment after Low-Dose Radiotherapy https://pubs.acs.org/doi/10.1021/acsnano.3c01428

Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers https://pubs.acs.org/doi/10.1021/acsnano.3c01811

μMESH-Enabled Sustained Delivery of Molecular and Nanoformulated Drugs for Glioblastoma Treatment https://pubs.acs.org/doi/10.1021/acsnano.3c01574

Effective nose-to-brain drug delivery using a combination system targeting the olfactory region in monkeys https://www.sciencedirect.com/science/article/pii/S0168365923003759

Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00183-6

Controlled delivery of a neurotransmitter–agonist conjugate for functional recovery after severe spinal cord injury https://www.nature.com/articles/s41565-023-01416-0

Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257

Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy https://www.science.org/doi/full/10.1126/sciadv.adf4098

Transforming Cancer-Associated Fibroblast Barrier into Drug Depots to Boost Chemo-Immunotherapy in “Shooting Fish in a Barrel” Pattern https://pubs.acs.org/doi/10.1021/acsnano.3c02272

Mapping Antibody Domain Exposure on Nanoparticle Surfaces Using DNA-PAINT https://pubs.acs.org/doi/10.1021/acsnano.3c02195

Synthesis, Characterization, and Biological Evaluation of Radiolabeled Glutamine Conjugated Polymeric Nanoparticles: A Simple Approach for Tumor Imaging https://pubs.acs.org/doi/10.1021/acsabm.3c00048

Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone https://www.mdpi.com/1999-4923/15/6/1580

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia https://www.science.org/doi/abs/10.1126/scitranslmed.abm1262

Efficacy and safety of nano-paclitaxel formulation for cancer treatment: evidence from randomized clinical trials https://www.futuremedicine.com/doi/full/10.2217/nnm-2023-0080

Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis https://www.science.org/doi/10.1126/sciadv.adf3887

Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery https://www.nature.com/articles/s41565-023-01381-8

Quality by Design as a Tool in the Optimisation of Nanoparticle Preparation—A Case Study of PLGA Nanoparticles https://www.mdpi.com/1999-4923/15/2/617

Nanoarchitecture-Integrated Hydrogel Systems toward Therapeutic Applications https://pubs.acs.org/doi/10.1021/acsnano.2c12448

Quantifying Intracellular Nanoparticle Distributions with Three-Dimensional Super-Resolution Microscopy https://pubs.acs.org/doi/10.1021/acsnano.2c12808

Can targeted nanoparticles distinguish cancer metastasis from inflammation? https://www.sciencedirect.com/science/article/abs/pii/S0168365923002456

Complex Structures Made Simple – Continuous Flow Production of Core Cross-Linked Polymeric Micelles for Paclitaxel Pro-Drug-Delivery https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202210704

Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00080-6

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00047-8

Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme https://www.nature.com/articles/s41598-023-32257-5

A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200518