Recently Published Research

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis https://www.nature.com/articles/s41565-025-02101-0

A Modular Vaccine Platform Against SARS-CoV-2 Based on Self-Assembled Protein Nanoparticles https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513431

Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery https://pubs.acs.org/doi/10.1021/acsnano.5c19431

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00545-5

Morphology control in benzoic imine-linked polymer-drug conjugates for adaptive drug delivery and enhanced in vivo efficacy https://www.sciencedirect.com/science/article/pii/S0014305726000054

Multimodal electroconductive PLGA-based scaffold orchestrates neuroprotection and regeneration following severe spinal cord injury https://link.springer.com/article/10.1186/s12951-025-03998-4

Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00455-2

Nanoparticles for Delivery of Encapsulated Drugs to Hypoxic Pancreatic Ductal Adenocarcinoma Cell Spheroids https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01395

Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy https://www.cell.com/cell/fulltext/S0092-8674(25)01421-7

Protein Nanovaccines Co-Delivering STING Agonists for Enhanced Dendritic Cell Activation and Antitumor Immunity https://pubs.acs.org/doi/10.1021/acsami.5c20468

PEGylated isothiocyanate-functionalized zinc(II) phthalocyanine exhibits cell-type dependent photodynamic activity in 2D and 3D tumor models https://www.sciencedirect.com/science/article/abs/pii/S1011134426000011

Serotonergic System-Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202521427

Single-Cell Morphomechanics of Prostate Cancer-Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202522440

Stroma-targeted gene delivery for efficient immunogene therapy against pancreatic cancer https://www.cell.com/molecular-therapy-family/molecular-therapy/abstract/S1525-0016(25)00813-5

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509590

Zinc Phthalocyanine Nanoassemblies Regulated by Polyethylene Glycol Chains for Synergistic Phototherapy https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01618

A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines https://www.nature.com/articles/s41467-025-66252-3

A biohybrid chiral hydrogel enhances preclinical postoperative glioblastoma therapy by multi-pronged inhibition of tumour stemness https://www.nature.com/articles/s41565-025-02064-2

A Novel Trained Immunity Adjuvant Derived From Commensal Bacteria Potentiates Liposome–Hydrogel Cancer Vaccine Against Breast Tumors https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202504705

A phase 1b/2 study of first-line anti-PD-L1/ TGF-βRII fusion protein SHR-1701 combined with nab-paclitaxel and gemcitabine for advanced pancreatic ductal adenocarcinoma https://www.nature.com/articles/s41392-025-02530-2

A Novel Trained Immunity Adjuvant Derived From Commensal Bacteria Potentiates Liposome–Hydrogel Cancer Vaccine Against Breast Tumors https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202504705

An ultrasmall core–shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments https://www.nature.com/articles/s41565-025-02083-z

Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries https://pubs.acs.org/doi/10.1021/acsnano.5c15613

Central Nervous System Targeting Nanovesicles for Trans-Barrier Delivery and Spinal Cord Injury Treatment https://pubs.acs.org/doi/10.1021/acsnano.5c08255

Collagen-Based Hydrogel Loaded With Microspheres Encapsulated With Placental Mesenchymal Stem Cells-Derived Exosomes Synergistically Promote Recovery After Spinal Cord Injury in Rat https://onlinelibrary.wiley.com/doi/10.1002/jbmb.70014

Machine perception liquid biopsy identifies brain tumours via systemic immune and tumour microenvironment signature https://www.nature.com/articles/s41565-025-02080-2

Mapping cellular targets of covalent cancer drugs in the entire mammalian body https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0

Mitochondrial transfer through tunneling nanotubes inspires an innovative strategy for intercellular drug delivery https://www.sciencedirect.com/science/article/abs/pii/S1742706125009559

Multifunctional poly(amino acid) nanomedicine modulates macrophage polarization for osteosarcoma immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925012064

Nano-purpurin-Cu delivery via TPGS-induced macropinocytosis enables cuproptosis/metabolic synergy to ablate cancer stemness and Boost immunotherapy in colorectal cancer https://www.sciencedirect.com/science/article/abs/pii/S014296122500794X

Nanorobots hold PD-L1 and break membrane of colorectal cancer cells for immunotherapy https://www.nature.com/articles/s41565-025-02071-3

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma https://www.nature.com/articles/s41598-025-32676-6

Octopus-inspired polymeric nanovaccine enables high antigen loading and robust T cell activation for cancer immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925011769

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism https://www.nature.com/articles/s41588-025-02446-1

Patient-derived geometry-integrated multiphysics framework: Computational optimization of immunotherapeutic nanoparticle delivery via tumor microenvironment reprogramming in prostate cancer https://www.sciencedirect.com/science/article/abs/pii/S0010482525017421

Poly(lactic-co-glycolic acid) Nanoparticles for IL-12 Self-Amplifying RNA Delivery in Glioblastoma Models https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202529443

Polymeric-Based Theranostic Nanocarriers of Neuroprotective Drugs: Development, Imaging, and Bioanalysis https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00170

Porphy-based drug-delivery nanoparticles for photodynamic therapy and photoactivated cascade chemotherapy https://pubs.rsc.org/en/content/articlelanding/2026/tb/d5tb02747k

Self-assembled nanoparticles of glycosylated AABB-type phthalocyanines for selective photodynamic therapy https://www.sciencedirect.com/science/article/pii/S0045206825012568

Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment https://www.science.org/doi/10.1126/sciadv.adu0292

Viral glycoprotein-mimicking peptide-functionalized micelles promote drug delivery to diseased chondrocytes for osteoarthritis alleviation https://www.nature.com/articles/s41565-025-02082-0

Zwitterionic Photosensitizer Triggers Photopyroptosis for Effective Cancer Immunotherapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202503451

A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions https://www.nature.com/articles/s41593-025-02123-w

A skin-permeable polymer for non-invasive transdermal insulin delivery https://www.nature.com/articles/s41586-025-09729-x

Activating PEG host to enable spatially controlled surface functionalization of nanocarriers for biomedical applications https://www.science.org/doi/full/10.1126/sciadv.adu3932

Albumin-Phthalocyanine Nanoconjugates as Platforms for Enhanced Photodynamic Cancer Therapy https://www.mdpi.com/1422-0067/26/23/11559

Autonomous Braking of Host-Guest Nanoparticles for Enhanced Tumor Tissue Penetration and Retention https://onlinelibrary.wiley.com/doi/10.1002/smll.202509060

Bioengineered photosynthetic nanothylakoids reshape the inflammatory microenvironment for rheumatoid arthritis therapy https://www.nature.com/articles/s41565-025-02063-3

Biomimetic core-shell GelMA microspheres co-delivering ANXA1, NGF, and fibronectin enable phase-matched immunomodulation and neurorepair after spinal cord injury https://www.thno.org/v16p0483.htm

Biotin-functionalized chitosan-based polyelectrolyte complex for encapsulation and photodynamic modulation of zinc(II) phthalocyanine https://www.sciencedirect.com/science/article/abs/pii/S014181302509854X

Cathepsin B-Cleavable Doxorubicin Prodrug Nanoparticles for Eliciting Cancer-Specific Immunogenic Cell Death and Minimizing Systemic Toxicity https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202504414

Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy https://pubs.acs.org/doi/10.1021/jacs.5c17598

Enhancing nanomedicine efficacy in KPC pancreatic tumors through Ketotifen-mediated tumor microenvironment remodeling https://www.sciencedirect.com/science/article/pii/S0168365925011551

Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation https://www.nature.com/articles/s41587-025-02865-9

Hyaluronic acid–chitosan conjugated PLGA nanoparticles for dual chemo-photothermal therapy of triple-negative breast cancer https://www.nature.com/articles/s41598-025-31485-1

In situ genetically engineering nanosystem for reversing immunosuppression of cancer-associated fibroblasts in breast cancer radiotherapy https://www.sciencedirect.com/science/article/abs/pii/S0142961225007148

Inhaled Micelle of Antimicrobial Protein-Polymer Conjugate with Less Positive Charge Leads to Better Mucus Penetration and Enhanced Gram-Negative Pneumonia Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202504626

Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs https://www.science.org/doi/abs/10.1126/scitranslmed.ado5177

Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD https://www.science.org/doi/abs/10.1126/scitranslmed.adv2293

Metalloporphyrin organic framework oxygen-generators enable tumour-targeted photodynamic therapy and metabolic reprogramming for enhanced glioblastoma treatment https://www.sciencedirect.com/science/article/abs/pii/S0021979725029133

Multifunctional Hyaluronic Acid/Graphite Nanoplatelet Hydrogels as Tools for Spinal Cord Regeneration https://pubs.acs.org/doi/10.1021/acsami.5c20777

Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition https://www.cell.com/iscience/fulltext/S2589-0042(25)02349-1

Nose-to-Brain Delivery of Donepezil Hydrochloride via Oleic Acid-Conjugated PAMAM G4 Dendrimers for the Treatment of Alzheimer’s-Like Dementia https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00761

Olaparib has synergistic effects with DNA damaging agents in pancreatic ductal adenocarcinoma https://www.sciencedirect.com/science/article/abs/pii/S0006291X25017966

Photodynamic Anticancer Efficacy of meso-tris-p-Carboxyphenylporphyrin-Fullerene Dyads: Apoptosis Induction and Mitochondrial Deregulation in Glioblastoma Therapy https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500449

Photosensitizing tetrahydroxyphenyl porphyrin/human serum albumin nanoparticles for potentiated photodynamic therapy https://www.sciencedirect.com/science/article/abs/pii/S0021979725030656

Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy https://www.nature.com/articles/s41467-025-66976-2

Polypeptide-based nanocarriers from aqueous ROPISA: Shape-dependent performance in colorectal and breast cancer models https://www.sciencedirect.com/science/article/pii/S0142961225007215

Pre-targeted delivery of a tetrazinylated albumin–zinc(ii) porphyrin complex for tumor photodynamic therapy https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc05967d

Programmable Antigen-Specific Immunity via Self-Adjuvanting Nanovaccines Co-Delivering Immune Modulators https://onlinelibrary.wiley.com/doi/10.1002/anie.202520474

Radiomics-based quantification of tumor infiltration in the non-enhancing peritumoral region on postoperative MRI is associated with survival in glioblastoma https://www.nature.com/articles/s41598-025-27711-5

Real-Time Observation of Tunneling Nanotube Dynamics and Its Mediated Intracellular ROS Regulation Using SICM and SECM https://pubs.acs.org/doi/10.1021/acs.analchem.5c06365

Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy https://www.nature.com/articles/s43018-025-01070-6

Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery https://www.sciencedirect.com/science/article/abs/pii/S0142961225007732

Stimuli-Sensitive Platinum-Based Anticancer Polymer Therapeutics: Synthesis and Evaluation In Vitro https://www.mdpi.com/1999-4923/17/11/1433

Structural design of porous organic polymers to mitigate π-stacking-induced quenching in porphyrin/phthalocyanine photosensitizers for enhanced antibacterial activity https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra08102e

Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer https://aacrjournals.org/mct/article/doi/10.1158/1535-7163.MCT-25-0505/770763/Targeting-tumor-microenvironment-derived-NRG1-HER2

The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage https://www.science.org/doi/full/10.1126/sciadv.adu2276

Thiourea-modified poly(l-lysine) carriers with multiple hydrogen bonding interactions for safe and robust mRNA vaccine therapy https://www.sciencedirect.com/science/article/abs/pii/S016836592500985X

Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-25-0433/770342/Transfer-of-Damaged-Mitochondria-from-Cancer-Cells

Tumor Mechanobiology-Inspired Nanomechanics: Piezo1 Mediated Tumor-Associated Macrophages Reprogramming and Exosome-Driven Immune Amplification https://pubs.acs.org/doi/10.1021/acsnano.5c14785

Tumor-acidity triggered detachment of surface coatings and charge-reversal of fluorinated polymeric micelles to boost photodynamic cancer therapy https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb02079d

αPD-1-conjugated acid-cleavable nanodrugs overcomes cellular immunotherapy barriers in pancreatic tumors https://www.nature.com/articles/s41467-025-67254-x

Aminophosphonate-Derived lipid nanoparticles enable circular RNA delivery for functional recovery after spinal cord injury https://www.sciencedirect.com/science/article/abs/pii/S1369702125004250

An activatable self-amplifying ROS nanoplatform for augmented Cerenkov radiation-induced photodynamic therapy https://pubs.rsc.org/en/content/articlelanding/2025/bm/d5bm01156f

Blood-brain barrier opening with neuronavigation-guided focused ultrasound in pediatric patients with diffuse midline glioma https://www.science.org/doi/full/10.1126/scitranslmed.adq6645

Cationic nanogel–based nasal therapeutic HPV vaccine prevents the development of cervical cancer https://www.science.org/doi/abs/10.1126/scitranslmed.ado8840

Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines https://www.nature.com/articles/s41565-025-02044-6

Disrupting CSPG-Driven Microglia–Astrocyte Crosstalk Enables Scar-Free Repair in Spinal Cord Injury https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516269

Effect of chemotherapeutic drugs and cytochalasin B on tunneling nanotubes in U87 MG cells https://bmccancer.biomedcentral.com/articles/10.1186/s12885-025-15204-7

Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial https://www.nature.com/articles/s41591-025-04049-z

Enzyme-powered micellar nanoreactors enable tumor-specific, cascade-amplified prodrug activation for synergistic oxidation–chemo–immunotherapy https://www.sciencedirect.com/science/article/pii/S0168365925009770

Enzyme-Assisted Selective Biosynthesis of Polyrotaxane Assemblies in Living Cells for Precision Supramolecular Phototherapy https://onlinelibrary.wiley.com/doi/10.1002/smll.202511673

IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer https://www.nature.com/articles/s41563-025-02390-9

Rolipram-Loaded PgP Nanotherapeutics via Intrathecal Administration Reduces Secondary Injury in a Rat Acute Moderate Contusion SCI Model https://onlinelibrary.wiley.com/doi/10.1002/jnr.70091

Metabolic reprogramming in amyotrophic lateral sclerosis ependymal stem cells by FM19G11 nanotherapy https://www.nature.com/articles/s41598-025-23553-3

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug-Releasing Capability for the Programmable Repair of Spinal Cord Injury https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510976

New concept of spectroscopic detection of the cationic porphyrin via its spontaneous aggregation at Au@thermoresponsive polymer core@shell nanocomposites https://www.sciencedirect.com/science/article/pii/S1386142525014660

Nucleophile-triggered prodrug release from polymer hydrogels https://pubs.rsc.org/en/content/articlelanding/2025/lp/d5lp00317b

Polydopamine-Coated Poly(l-lactide) Nanofibers with Controlled Release of IL-10 for Effective Management of Peripheral and Central Neuropathic Pain in Rats https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c01638