Recently Published Research

All the new interesting studies relating to the research underway in the Polymer Therapeutics Lab!

A unified biochemical–physical regulatory nanoparticle modulates tumor mechanics to augment nanomedicine penetration and antitumor efficacy https://www.sciencedirect.com/science/article/abs/pii/S0168365926002348

Amino acid composition drives aggregation during peptide synthesis https://www.nature.com/articles/s41557-026-02090-0

Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination https://www.nature.com/articles/s41563-026-02512-x

Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202522617

Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies https://www.science.org/doi/abs/10.1126/scitranslmed.ads9088

Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy https://www.nature.com/articles/s41565-025-02102-z

Smart Macrocycles: Cyclodextrin−Porphyrin Photosensitizers for Photodynamic Therapy in Human Bladder Cancer Cells https://pubs.acs.org/doi/10.1021/acsabm.6c00053

Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel https://www.science.org/doi/full/10.1126/sciadv.adz7615

3D-Printed, Cellulose-Derived Scaffold Promotes Neuroregeneration and Functional Recovery after Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c02180

A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization https://pubs.rsc.org/en/content/articlelanding/2026/ra/d5ra08918b

Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models https://www.science.org/doi/abs/10.1126/scitranslmed.adx4097

AND logic nanoparticle for precision immunotherapy of metastatic cancers https://www.nature.com/articles/s41565-026-02130-3

Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion https://www.science.org/doi/full/10.1126/sciadv.adz1722

Co-delivery nanoparticle targeting CAF for simultaneous activating T cell plus NKT cell attack in solid tumor https://www.sciencedirect.com/science/article/pii/S2090123226002316

Dendritic cell-targeted tumor antigen delivery by glucosylated lipid nanoparticles for precision tumor immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365926000726

Glycosylated Multifunctional Nanoplatform Co-Delivering Artemisinin: Synergizing NIR-Responsive Phototherapy with Chemodynamic Therapy for Precision-Targeted Tumor Theranostics https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202503975

In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery https://www.nature.com/articles/s41587-026-03022-6

Injectable Metal-Free Carbon Dot-Integrated Hydrogel for Regulating Inflammation via Macrophage Metabolic Reprograming in Spinal Cord Injury Therapy https://pubs.acs.org/doi/10.1021/acsnano.5c13627

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy https://www.cell.com/cell/fulltext/S0092-8674(26)00173-X

Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization https://www.nature.com/articles/s41563-026-02519-4

A STING signaling relay from tumor cells to macrophages mediates the improved efficacy of combination chemotherapy in pancreatic cancer https://link.springer.com/article/10.1186/s12929-026-01226-1

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502758

Crosslinking of lipid nanoparticles enhances the delivery efficiency and efficacy of mRNA vaccines https://www.nature.com/articles/s44286-026-00356-5

Extracellular Vesicle-Mediated Precision Delivery of Paclitaxel Activates Mitophagy to Promote Repair after Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsnano.5c21273

In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy https://www.nature.com/articles/s41563-026-02506-9

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature https://www.cell.com/cell/fulltext/S0092-8674(26)00111-X

Matrix Metalloproteinase-Activatable Nanodrug Crossing Blood–Spinal Cord Barrier for On-Demand Drug Release in Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsnano.5c21926

Mitochondria transfer in Glioblastoma https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noag038/8495128

Neonatal Spinal-Cord-Like Scaffold with Hierarchical Structural and Neurogenetic Microenvironments for Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsnano.5c07071

Photo-responsive polyprodrug supramolecular assemblies with self-accelerated subcellular delivery for synergistic photochemotherapy https://www.sciencedirect.com/science/article/abs/pii/S2095927326000034

Photodynamic Therapeutic Monitoring of Glioblastoma Using High-Resolution Photoacoustic Vascular Imaging https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01785

Precancerous niche remodelling dictates nascent tumour persistence https://www.nature.com/articles/s41586-026-10157-8

Protein-based nanocarriers in the management of hard-to-treat solid tumours https://www.sciencedirect.com/science/article/pii/S0169409X26000761

Rescue Radiosensitization of Pancreatic Cancer via PD-L1/TGF-β1 Dual-Blockade Nanotherapy as Evaluated in 3-Dimensional Microtumors https://spj.science.org/doi/10.34133/bmr.0335

Self-amplifying ROS nanorobot with orthogonal NIR activation for enhanced photodynamic–chemodynamic combination therapy https://pubs.rsc.org/en/content/articlelanding/2026/bm/d5bm01705j

Whole-organ and whole-body 3D atlases enable cellome-wide profiling https://www.cell.com/cell/abstract/S0092-8674(25)01507-7

3D-Printed, Cellulose-Derived Scaffold Promotes Neuroregeneration and Functional Recovery after Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c02180

Bioinspired Sericin-PCL Nanoparticles for Sustained Delivery in Cancer with Antioxidant and Antibacterial Efficacies https://link.springer.com/article/10.1007/s12668-026-02436-5

Decellularized Dermis ECM-Based Melanoma-on-a-Chip Model with Integrated Lymphatic and Vascular Networks for High-Throughput Drug Testing https://pubs.acs.org/doi/10.1021/acsabm.5c02329

Injectable ε-poly-lysine/hyaluronic acid hydrogel for targeted prevention of cardiovascular implantable electronic device pocket infections https://pubs.rsc.org/en/content/articlehtml/2026/ra/d5ra08511j

Nanoformulated fingolimod attenuates NLRP3 inflammasome activation and promotes functional recovery in a rat model of spinal cord injury https://www.nature.com/articles/s41393-026-01177-2

Nanovaccines of polydopamine@tumor-associated antigens with robust prophylactic and therapeutic efficacy for cancer immunotherapy https://pubs.rsc.org/en/content/articlelanding/2026/nh/d5nh00681c

Neonatal Spinal-Cord-Like Scaffold with Hierarchical Structural and Neurogenetic Microenvironments for Spinal Cord Injury Repair https://pubs.acs.org/doi/10.1021/acsnano.5c07071

Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial https://www.cell.com/cell/abstract/S0092-8674(25)01504-1

Reprogramming the In Vivo Fate of Nanoassemblies: Morphology Regulation to Rod-Like Nanostructures to Enhance Antitumor Efficacy https://pubs.acs.org/doi/10.1021/acsami.5c25772

Selective mRNA Delivery to Activated Macrophages via Hyaluronic Acid-Functionalized Lipid Nanoparticles with Optimized PEGylation https://pubs.acs.org/doi/10.1021/acs.biomac.5c02390

Divergent tumor immunity determined by bacteria-cancer cell engagement https://www.cell.com/cell/abstract/S0092-8674(25)01493-X

Evaluation of PLGA nanoparticle-based conjugate vaccines incorporating lipopolysaccharide and alginate for inducing immunity against P. aeruginosa: a rabbit model study https://www.tandfonline.com/doi/full/10.1080/09205063.2026.2614052

Mitochondrial transfer in the HSC–HCC–macrophage network shapes hepatocellular carcinoma progression https://www.pnas.org/doi/10.1073/pnas.2512592123

Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00455-2

Nanoparticle-Assembled Multifaceted Hydrogel Therapy Promotes Functional Recovery After Spinal Cord Injury https://pubs.acs.org/doi/10.1021/acsnano.5c21336

Self-Amplified Nanomedicine Enables Lysosomal Blockade to Potentiate Starvation Therapy of Pancreatic Ductal Adenocarcinoma https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202519523

Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy https://link.springer.com/article/10.1186/s12951-026-04062-5

Translational m-PBPK Modeling reveals active transcytosis as the pivotal mechanism for nanoparticle tumor delivery: Implications for dose optimization https://www.sciencedirect.com/science/article/pii/S0168365926000854

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis https://www.nature.com/articles/s41586-025-10028-8

Machine Learning-Enhanced Engineering of Ultrahigh-Loading Polymer-Drug Assemblies with Programmable ROS-Triggered Release for Tumor Elimination https://www.scilit.com/publications/a705f5b86196fa008acedaa9d1ab9fba

A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma https://www.science.org/doi/full/10.1126/scitranslmed.adt1211

A Patient-Derived Organ-on-Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508934

An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery https://www.cell.com/cell/abstract/S0092-8674(25)01434-5

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth https://www.cell.com/cancer-cell/abstract/S1535-6108(25)00555-0

Biomimetic vesicles engineered from modified tumour cells act as personalized vaccines for post-surgical cancer immunotherapy https://www.nature.com/articles/s41565-025-02113-w

DNA nanodevices detect an acidic nanolayer on the lysosomal surface https://www.nature.com/articles/s41556-025-01855-y

Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice https://www.cell.com/cell-host-microbe/abstract/S1931-3128(25)00533-5

Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery https://pubs.acs.org/doi/10.1021/acsnano.5c19431

Hyaluronic Acid-Coated DNA Nanoflowers as Smart Nanocarriers for Deep Tumor Penetration and Enhanced Gene Therapy in Pancreatic Cancer https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202531547

Intraneural delivery of CBD3A6K-RhB via PEG-PLGA nanoparticles for neuropathic pain therapy https://www.sciencedirect.com/science/article/abs/pii/S0168365926000635

Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination–proficient prostate cancer https://www.pnas.org/doi/10.1073/pnas.2515790122

Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models https://www.cell.com/cell-stem-cell/abstract/S1934-5909(26)00024-X

Nanovaccine Based on Glycocalyx-Mimicking Nanovehicle to Potentiate the Immunogenicity of Neoantigen https://pubs.acs.org/doi/10.1021/acsmacrolett.5c00712

Oxidation-activated nanotherapy boosts tumor immunity and disrupts tumor-nerve crosstalk to combat bone metastases and cancer pain https://www.science.org/doi/10.1126/sciadv.ady1292

Polydopamine-Based Light Responsive Nanoparticles with Magnetic Resonance Imaging Capabilities for Breast Cancer Photodynamic/Photothermal Therapy Combination Therapy https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500617

Prostate-specific membrane antigen targeted organic semiconducting polymer nanoparticles for enhanced photothermal therapy of prostate cancer https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1688048/full

Spatiotemporal targeting of messenger RNA lipid nanoparticles to the endometrium for the treatment of reproductive disorders https://www.nature.com/articles/s41565-025-02108-7

A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis https://www.nature.com/articles/s41565-025-02101-0

A Modular Vaccine Platform Against SARS-CoV-2 Based on Self-Assembled Protein Nanoparticles https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513431

Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery https://pubs.acs.org/doi/10.1021/acsnano.5c19431

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00545-5

Morphology control in benzoic imine-linked polymer-drug conjugates for adaptive drug delivery and enhanced in vivo efficacy https://www.sciencedirect.com/science/article/pii/S0014305726000054

Multimodal electroconductive PLGA-based scaffold orchestrates neuroprotection and regeneration following severe spinal cord injury https://link.springer.com/article/10.1186/s12951-025-03998-4

Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00455-2

Nanoparticles for Delivery of Encapsulated Drugs to Hypoxic Pancreatic Ductal Adenocarcinoma Cell Spheroids https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01395

Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy https://www.cell.com/cell/fulltext/S0092-8674(25)01421-7

Protein Nanovaccines Co-Delivering STING Agonists for Enhanced Dendritic Cell Activation and Antitumor Immunity https://pubs.acs.org/doi/10.1021/acsami.5c20468

PEGylated isothiocyanate-functionalized zinc(II) phthalocyanine exhibits cell-type dependent photodynamic activity in 2D and 3D tumor models https://www.sciencedirect.com/science/article/abs/pii/S1011134426000011

Serotonergic System-Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202521427

Single-Cell Morphomechanics of Prostate Cancer-Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202522440

Stroma-targeted gene delivery for efficient immunogene therapy against pancreatic cancer https://www.cell.com/molecular-therapy-family/molecular-therapy/abstract/S1525-0016(25)00813-5

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509590

Zinc Phthalocyanine Nanoassemblies Regulated by Polyethylene Glycol Chains for Synergistic Phototherapy https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01618

A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines https://www.nature.com/articles/s41467-025-66252-3

A biohybrid chiral hydrogel enhances preclinical postoperative glioblastoma therapy by multi-pronged inhibition of tumour stemness https://www.nature.com/articles/s41565-025-02064-2

A Novel Trained Immunity Adjuvant Derived From Commensal Bacteria Potentiates Liposome–Hydrogel Cancer Vaccine Against Breast Tumors https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202504705

A phase 1b/2 study of first-line anti-PD-L1/ TGF-βRII fusion protein SHR-1701 combined with nab-paclitaxel and gemcitabine for advanced pancreatic ductal adenocarcinoma https://www.nature.com/articles/s41392-025-02530-2

An ultrasmall core–shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments https://www.nature.com/articles/s41565-025-02083-z

Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries https://pubs.acs.org/doi/10.1021/acsnano.5c15613

Central Nervous System Targeting Nanovesicles for Trans-Barrier Delivery and Spinal Cord Injury Treatment https://pubs.acs.org/doi/10.1021/acsnano.5c08255

Collagen-Based Hydrogel Loaded With Microspheres Encapsulated With Placental Mesenchymal Stem Cells-Derived Exosomes Synergistically Promote Recovery After Spinal Cord Injury in Rat https://onlinelibrary.wiley.com/doi/10.1002/jbmb.70014

Machine perception liquid biopsy identifies brain tumours via systemic immune and tumour microenvironment signature https://www.nature.com/articles/s41565-025-02080-2

Mapping cellular targets of covalent cancer drugs in the entire mammalian body https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0

Mitochondrial transfer through tunneling nanotubes inspires an innovative strategy for intercellular drug delivery https://www.sciencedirect.com/science/article/abs/pii/S1742706125009559

Multifunctional poly(amino acid) nanomedicine modulates macrophage polarization for osteosarcoma immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925012064

Nano-purpurin-Cu delivery via TPGS-induced macropinocytosis enables cuproptosis/metabolic synergy to ablate cancer stemness and Boost immunotherapy in colorectal cancer https://www.sciencedirect.com/science/article/abs/pii/S014296122500794X

Nanorobots hold PD-L1 and break membrane of colorectal cancer cells for immunotherapy https://www.nature.com/articles/s41565-025-02071-3

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma https://www.nature.com/articles/s41598-025-32676-6

Octopus-inspired polymeric nanovaccine enables high antigen loading and robust T cell activation for cancer immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0168365925011769

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism https://www.nature.com/articles/s41588-025-02446-1

Patient-derived geometry-integrated multiphysics framework: Computational optimization of immunotherapeutic nanoparticle delivery via tumor microenvironment reprogramming in prostate cancer https://www.sciencedirect.com/science/article/abs/pii/S0010482525017421