Recently Published Research

• A dependency map enhanced with next-generation 3D cancer models https://www.nature.com/articles/s41586-026-10843-7
• A transferable gut microbiota–bile acid pathway programs nanomedicine pharmacokinetics and therapeutic response https://www.nature.com/articles/s41563-026-02690-8
• A tumour-derived organoid biobank maps cancer gene dependencies https://www.nature.com/articles/s41586-026-10830-y
• A Versatile Tumor Microenvironment-Responsive Nanoprobe for Cancer Screening and Early Detection https://pubs.acs.org/jacsat/article-abstract/148/29/31263/5237481/A-Versatile-Tumor-Microenvironment-Responsive
• An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73878
• Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00661-3
• Dual-Drug Polymer Conjugates of Gemcitabine and Hydroxychloroquine for Pancreatic Cancer: The Critical Role of Linker Chemistry https://pubs.acs.org/aapmcd/article/doi/10.1021/acsapm.6c02161/5236390
• Evaluating the impact of dynamic fluid flow on an advanced model of pancreatic cancer: Towards desmoplasia disruption and chemosensitivity promotion https://www.sciencedirect.com/science/article/pii/S2772950826002827
• Human spinal interneurons repair the injured rat spinal cord through synaptic integration https://www.science.org/doi/abs/10.1126/scitranslmed.aea7461
• Injectable and sprayable supramolecular prodrug hydrogel for long-acting chemo-hormonal therapy of prostate cancer https://www.sciencedirect.com/science/article/abs/pii/S0168365926006243
• Light-responsive polyphosphoester nanocarriers for cascade-amplified synergistic photodynamic-chemotherapy of colon cancer https://www.sciencedirect.com/science/article/abs/pii/S0927776526004455
• Near-infrared light-triggered, self-amplifying targeted drug-delivery platform achieves precision treatment of retinoblastoma https://www.sciencedirect.com/science/article/abs/pii/S0378517326005247
• Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer https://www.nature.com/articles/s41467-026-74334-z
• Redox-responsive polymeric nanocarriers for targeted delivery of bruceantin to pancreatic cancer https://pubs.rsc.org/nr/article-abstract/doi/10.1039/d6nr00636a/1288324/Redox-responsive-polymeric-nanocarriers-for
• Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy https://www.science.org/doi/abs/10.1126/scitranslmed.aeb8054
• Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ https://www.nature.com/articles/s41556-026-02013-8
• Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer https://www.nejm.org/doi/full/10.1056/NEJMoa2605555
• Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing postoperative blood-brain barrier disruption https://www.science.org/doi/abs/10.1126/scitranslmed.adv8761
• A Carrier-Free Peptide Nanomedicine Orchestrates Dual Redox Therapy via Ferroptosis and Disulfidptosis https://pubs.acs.org/aamick/article-abstract/doi/10.1021/acsami.6c08792/5222707/A-Carrier-Free-Peptide-Nanomedicine-Orchestrates
• A multimodal synergistic anti-glioblastoma strategy based on nano-sonodynamic therapy https://pubs.rsc.org/nr/article-abstract/doi/10.1039/d6nr01554a/1281019/A-multimodal-synergistic-anti-glioblastoma
• Catalytic profiling of extracellular vesicles maps altered cancer metabolism https://www.nature.com/articles/s41565-026-02230-0
• Combining an αvβ6-Targeted 177Lu-Based Peptide Receptor Radionuclide Therapy with Olaparib to Boost Therapeutic Efficacy in Pancreatic Cancer https://jnm.snmjournals.org/content/early/2026/07/16/jnumed.125.271137
• Enzymatic degradation of Hyaluronic acid/Poly-l-Lysine capsules for burst drug release https://www.sciencedirect.com/science/article/abs/pii/S0008621526002387
• Immunostimulatory lipogel implant enhances cancer immunotherapy https://www.nature.com/articles/s41565-026-02194-1
• Loading is not delivering: Intracellular drug retention and migration capacity govern macrophage-based drug delivery https://www.science.org/doi/10.1126/sciadv.aec0429
• Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic cancer https://www.nature.com/articles/s41467-026-75883-z
• Thermosensitive Pluronic F127 Micelles for Piperlongumine Delivery: Selective ROS Amplification to Potentiate Cisplatin Efficacy in 3D Lung Cancer Spheroids https://pubs.acs.org/aapmcd/article/doi/10.1021/acsapm.6c01197/5214704/Thermosensitive-Pluronic-F127-Micelles-for
• Tumor-targeted CD40 ligand-functionalized extracellular vesicle mimetics enable chemoimmunotherapy for neuroblastoma https://www.sciencedirect.com/science/article/abs/pii/S0168365926006103
• “Alkaline-Hammer Strategy” Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer https://onlinelibrary.wiley.com/doi/10.1002/anie.8734845
• Dendritic Lipopeptide Nanovaccines Orchestrate Multi-Pattern Recognition Receptors Activation and Potentiate Antitumor Immunity https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73533
• Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers https://pubs.acs.org/doi/10.1021/acs.biomac.6c00159
• EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma https://www.science.org/doi/abs/10.1126/scitranslmed.adx8398
• Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells https://www.nature.com/articles/s41557-026-02195-6
• Long-range extended chains arising from polymerization-driven spontaneous assembly https://www.science.org/doi/10.1126/science.aef1777
• Mechano-reprogramming of tumor-associated macrophages by engineering nanogel stiffness for suppression of tumor development https://link.springer.com/article/10.1186/s12951-026-04793-5
• Mitochondrial complex I inhibition remodels the PDAC fibrotic microenvironment via LOXL2 suppression to potentiate chemo-immunotherapy https://www.sciencedirect.com/science/article/abs/pii/S0014299926006230
• Modular in vivo antibody–ADC click to reverse drug resistance in tumours https://www.nature.com/articles/s41586-026-10789-w
• Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers https://www.sciencedirect.com/science/article/pii/S1549963426000882
• Orthogonal Chemistry Enables Precision Nanoparticle Cofunctionalization for Tuning Immune Stimulation and Antigen Presentation https://pubs.acs.org/doi/10.1021/acs.biomac.5c02689
• Rhein-Mn coordination nanomedicine for peritoneal metastatic colorectal cancer: synergistic mitochondrial targeting, immunogenic cell death, and reverses immunosuppression https://link.springer.com/article/10.1186/s12951-026-04556-2
• Thermoresponsive Injectable Self-Healing Hydrogel Loaded with Self-Regenerating Photothermal Agent for Synergistic Photothermal–Thermodynamic–Chemodynamic Therapy for Pancreatic Cancer https://www.mdpi.com/2073-4360/18/13/1620
• Tutorial: strategies for targeting organelles using nanoparticles https://www.nature.com/articles/s41596-026-01401-6
• Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers https://pubs.acs.org/doi/10.1021/acs.biomac.6c00159
• Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells https://www.nature.com/articles/s41557-026-02195-6
• EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma https://www.science.org/doi/abs/10.1126/scitranslmed.adx8398?af=R
• Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers https://www.sciencedirect.com/science/article/pii/S1549963426000882
• Long-range extended chains arising from polymerization-driven spontaneous assembly https://www.science.org/doi/10.1126/science.aef1777
• Mechano-reprogramming of tumor-associated macrophages by engineering nanogel stiffness for suppression of tumor development https://link.springer.com/article/10.1186/s12951-026-04793-5
• Dendritic Lipopeptide Nanovaccines Orchestrate Multi-Pattern Recognition Receptors Activation and Potentiate Antitumor Immunity https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73533
• A zinc-coordinated cascade-responsive therapeutic nanoassembly for remodeling the pathological microenvironment and restoring mitochondrial homeostasis in spinal cord injury https://link.springer.com/article/10.1186/s12951-026-04760-0
• An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73878
• Arc mediates intercellular tau transmission via extracellular vesicles https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1
• Biomimetic adhesive hydrogel microcarriers for gas therapy and chemotherapy of gastric cancer https://www.sciencedirect.com/science/article/abs/pii/S1742706126003843
• Chirality-controlled seeded supramolecular polymerization: From glutamide amphiphiles to ultralong helical nanotubes https://www.sciencedirect.com/science/article/abs/pii/S0021979726012142
• Discovery and therapeutic delivery of microRNAs targeting deregulated glioblastoma pathways inhibits tumor growth in mice https://www.jci.org/articles/view/195639
• The intravenous targeted nanopeptide, CAQK, is neuroprotective and improves motor function after spinal cord injury in rats https://journals.lww.com/jtrauma/abstract/9900/the_intravenous_targeted_nanopeptide,_caqk,_is.1429.aspx
• Modulating IL-11-dependent matrix stiffness to delay ovarian aging https://www.nature.com/articles/s43587-026-01159-2
• Opposing intracellular redox modulation by a carrier-free diselenide nanosystem integrates antifibrosis and ferroptosis sensitization for fibrotic pancreatic cancer therapy https://www.sciencedirect.com/science/article/abs/pii/S0142961226004096
• PBAE nanoparticle-mediated delivery of ASCL1 and NGN2 genes for astroglia-to-neuron reprogramming to remodel glial scar for spinal cord injury repair https://link.springer.com/article/10.1186/s13287-026-05159-2
• Size switchable nanomodulator achieving ratio-precise dual-drug codelivery for synergistic glutamine metabolism modulation in pancreatic cancer https://www.sciencedirect.com/science/article/abs/pii/S0142961226004308
• Therapeutic reprogramming of tumour-associated macrophages in pancreatic cancer using a cytotoxic CCR2-targeted nanotheranostic https://link.springer.com/article/10.1186/s12943-026-02597-7